Professor; Director, Nuclear Magnetic Resonance Research Resource (NMR3)


Related information

Department of Chemistry

Phone: 902-494-4632
Mailing Address:

Department of Biochemistry & Molecular Biology
Dalhousie University
5850 College St., Room 9-B1
PO Box 15000
Halifax, NS B3H 4R2

Research Topics:

  • Physical chemistry
  • Biological chemistry
  • Computational chemistry
  • Spectroscopy
  • NMR spectroscopy
  • Scanning probe microscopy
  • Structural biology
  • Protein chemistry
  • Protein engineering


  • BSc, University of Guelph
  • MSc, University of Toronto
  • PhD, University of Toronto
  • PDF, University of Alberta

Research interests

Our focus is characterization and tailoring of protein structure and function in environments such as cell membranes or supramolecular assemblies. NMR and optical spectroscopy are employed alongside single molecule methods, with computational methods developed to correlate data from disparate techniques.

Selected awards and honours

  • Canadian Institutes of Health Research New Investigator Award, 2012-2017
  • Natural Sciences and Engineering Research Council of Canada Postdoctoral Fellowship, 2004-2006
  • Alberta Heritage Foundation for Medical Research Postdoctoral Fellowship, 2003-2006
  • Natural Sciences and Engineering Research Council of Canada Postgraduate Scholarship, 2000-2002

Selected publications

  • “Apelin conformational and binding equilibria upon micelle interaction primarily depend on membrane-mimetic headgroup.” K. Shin, M. Sarker, S.K. Huang and Jan K. Rainey* (Sci. Rep., 2017, 7: 15433)
  • Structural and mechanical roles for the C-terminal non-repetitive domain become apparent in recombinant spider aciniform silk.” L. Xu, T. LefèvreK.E. Orrell, Q. Meng, M. Auger, X-Q. Liu* and Jan K. Rainey* (Biomacromolecules, 2017, 18, 3678-3686)
  • “Preserved transmembrane segment topology, structure, and dynamics in disparate micellar environments.“ D.N. Langelaan, A. Pandey, M. Sarker and Jan K. Rainey* (J. Phys. Chem. Lett., 2017, 8, 2381-2386)
  • “Tracking transitions in spider wrapping silk conformation and dynamics by 19F nuclear magnetic resonance spectroscopy.” M. Sarker, K.E. Orrell, L. Xu, M-L. Tremblay, J.J. Bak, X-Q. Liu and Jan K. Rainey* (Biochemistry, 2016, 55, 3048-3059.)
  • “Characterization of variant soft nanoparticle structure and morphology in solution by NMR spectroscopy. “ M. Sarker, R.E. Fraser, M.D. Lumsden, D.J. Anderson and Jan K. Rainey* (J. Phys. Chem. C, 2015, 119, 7461-7471)