Janie Wilson

Director, Professor, School of Biomedical Engineering

J. Wilson


Janie Wilson, PhD
Email: janie.wilson@dal.ca
Phone: 902-494-6950
Web: www.dal.ca/dohmlab

My research program focusses on the development of biomechanical and statistical modeling techniques for understanding the mechanical pathways of knee osteoarthritis development and progression, and to optimize treatment strategies, including total knee replacement.

Our Group

My laboratory, the Dynamics of Human Motion lab, is a biomechanics facility that is designed primarily for three-dimensional gait analysis, with state of the art motion capture equipment, force platforms within a 6-meter walkway, and a strength testing system. We host a steady stream of research participants with varying levels of knee osteoarthritis (OA), from asymptomatic healthy adults, to those with an early diagnosis of knee OA, and then to the end stages of the disease process before and after surgery. We use this large and comprehensive dataset of human mechanics to model features of disease initiation, progression and response to treatment. 


Gait Mechanics Before and After Total Knee Replacement Surgery: I am examining the change in knee joint and muscle mechanics (knee kinematics, kinetics and neuromuscular control) before and after surgery in a large cohort of participants with end stage knee osteoarthritis. Novel statistical and biomechanical modeling techniques are used to identify subgroups among patients who cluster in terms of their joint-level mechanics and how they respond to surgery. (CIHR-funded)
Longitudinal Knee OA Development and Progression and Risk Factor Models: I am examining the role of joint kinematics, kinetics and neuromuscular control in the longitudinal structural development and progression of knee osteoarthritis in a large cohort of participants with and without existing diagnosed knee OA. I am specifically looking at the interacting role between two potent knee OA risk factors, obesity and female sex, to examine biomechanical pathways for their role in knee OA pathomechanics. (NSHRF-funded)
Joint Kinetics Modeling in the Study of Knee Osteoarthritis: I am developing and implementing a series of both statistical and biomechanical modeling tools for improved joint-level force prediction, in terms of accuracy of magnitude and pattern of force profiling. Models include behavioral models that capture and use subject-specific muscle activation, joint kinematics and net resultant kinetics, and anatomy to calculate inter-segmental joint contact forces during dynamic tasks. Statistical models aim to succinctly capture the joint mechanics variability among participants in an effort to reduce volumes of data collected during gait trials and to objectively quantify salient features within the data that have discriminative ability relative to knee osteoarthritis. (NSERC-funded)


Selected Publications

The reliability of radiostereometric analysis in determining physeal motion in slipped capital femoral epiphysis in standard uniplanar and low-dose EOS biplanar radiography. A phantom model study. Hurry JK, Rehan S, Astephen Wilson JL, Spurway A, Logan K, El-Hawary R. Journal of Pediatric Orthopaedics. 2018. In Press.
Asymptomatic and symptomatic individuals with the same radiographic evidence of knee osteoarthritis walk with different knee moments and muscle activity. Astephen Wilson JL, Stanish WD, Hubley-Kozey CL.  J Orthop Res. 2017 Aug;35(8):1661-1670. doi: 10.1002/jor.23465. Epub 2016 Nov 1.
Loading rate increases during barefoot running in habitually shod runners: Individual responses to an unfamiliar condition. Tam N, Astephen Wilson JL, Coetzee DR, van Pletsen L, Tucker R. Gait Posture. 2016 May;46:47-52. doi: 10.1016/j.gaitpost.2016.02.013. Epub 2016 Feb 22.
Astephen Wilson JL, Harding G, Dunbar MJ, Stanish WD, Hubley-Kozey CL. 2014. Obesity and the Presence of Moderate Knee Osteoarthritis Affect Tibiofemoral Contact Forces during Gait. Osteoarthritis and Cartilage (submitted).
Wilson DA, Astephen Wilson JL, Richardson G, Dunbar MJ. 2014. Changes in the functional flexion axis of the knee before and after total knee arthroplasty using a navigation system. Journal of Arthroplasty. Jul; 29(7): 1388-93.
Astephen Wilson JL, Dunbar MJ, Hubley-Kozey CL. 2014. Biomechanical and Neuromuscular Changes during Gait after Total Knee Arthroplasty are Sex-Specific. Journal of Arthroplasty (In Press).
Tam N, Astephen Wilson JL, Noakes TD, Tucker R. 2014. Barefoot Running: An Evaluation of Current Hypothesis, Future Research, and Clinical Applications, British Journal of Sports Medicine, March, 48(5), 349-55.
Robbins S, Astephen Wilson JL, Rutherford DJ, Hubley-Kozey CL. 2013. Reliability of Principal Components and Discrete Parameters of Knee Angle and Moment Gait Waveforms in Individuals with Moderate Knee Osteoarthritis. Gait and Posture. July, 38(3), 421-7.
Harding GT, Hubley-Kozey CL, Stanish WD, Dunbar MJ, Astephen Wilson JL. 2012. Body Mass Index Affects Knee Joint Mechanics during Gait Differently with and without Moderate Knee Osteoarthritis. Osteoarthritis and Cartilage. Nov; 20(11): 1234-42.
RD Roda, JL Astephen Wilson, DAJ Wilson, G Richardson, MJ Dunbar. 2012. The Knee Adduction Moment during Gait is Associated with the Adduction Angle Measured during Computer-Assisted Total Knee Arthroplasty, Journal Arthroplasty. Jun; 27(6): 1244-50
Wilson DAJ, Hubley-Kozey CL, Astephen Wilson JL, Dunbar MJ. 2012. Preoperative Muscle Activation Patterns During Walking Affect Tibial Implant Migration. Clinical Biomechanics. 27(9), 936-942.
Astephen Wilson JL. (2012) Challenges in Dealing with Walking Speed in Knee Osteoarthritis Gait Analysis. Clinical Biomechanics Mar; 27(3):210-212.
Astephen Wilson JL, Deluzio KJ, Dunbar MJ, Hubley-Kozey CL. 2011. The association between knee joint biomechanics and neuromuscular control and moderate knee osteoarthritis radiographic and pain severity. Osteoarthritis and Cartilage. Feb; 19(2): 186-93.
Hatfield G, Hubley-Kozey CL, Dunbar MJ, Astephen Wilson JL. 2011. The effect of total knee arthroplasty on knee joint kinematics and kinetics during gait. Journal of Arthroplasty; Feb;26(2): 309-18.
Hubley-Kozey CL, Hatfield G, Astephen Wilson JL, Dunbar MJ. 2010. Alterations in neuromuscular patterns between pre and one-year post-total knee arthroplasty. Clinical Biomechanics; Dec. 25(10); 995-1002.
Astephen Wilson JL, Wilson DAJ, Dunbar MJ, Deluzio KJ. 2010. Preoperative gait patterns and BMI are associated with postoperative tibial component migration in total knee arthroplasty. Acta Orthopaedica. Aug;81(4):478-86.
Wilson DAJ, Astephen JL, Hennigar AW, Dunbar MJ. 2010. Inducible Displacement of a Trabecular Metal Tibial Monoblock Component. Journal of Arthroplasty. Sep;25(6):893-900.
Astephen JL, Deluzio KJ, Caldwell GE, Dunbar MJ, Hubley-Kozey CL. 2008. Gait and Neuromuscular Patterns Associated with Differences in Knee Osteoarthritis Severity Levels. Journal of Biomechanics. 41(4), 868-76.
Astephen JL, Deluzio KJ, Caldwell GE, Dunbar MJ. 2008. Biomechanical Changes at the Hip, Knee and Ankle Joints During Gait are Associated with Knee Osteoarthritis Severity. Journal of Orthopedic Research. Mar 26(3), 332-41.
Deluzio KJ, Astephen JL. 2007. Biomechanical Features of Gait Waveform Data Associated with Knee Osteoarthritis. An Application of Principal Component Analysis. Gait and Posture. Jan 25(1), 86 – 93.