Jian WangPhD

Professor

shcd-jwang

Email: wangj4@dal.ca
Phone: 902-494-5149
Fax: 902-494-5151
Mailing Address: 
Sir Charles Tupper Medical Building
5850 College Street
2nd Floor, Room 2C01
PO Box 15000
Halifax, Nova Scotia
B3H 4R2
 

Bio

Dr. Jian Wang received a master’s degree in physiology in 1989 from the Southeast University of Nanjing, China, where he served as a medical school teacher for several years. He received a master’s degree in audiology in 1998 and a PhD in hearing science in 2000 from the State University of New York at Buffalo. He joined the faculty at the School of Communication Sciences and Disorders in 2001. He teaches basic courses in hearing science and instrumentation for audiology, as well as a seminar in selected topics in audiology.

Dr. Wang’s publications and presentations focus on a variety of topics in hearing science, including: cochlear gene therapy for the prevention of hearing loss due to aging, noise and ototoxic drugs, mechanisms of noise-induced hearing loss, and coding and plasticity in the auditory system induced by hearing loss.

Dr. Wang is currently the principal investigators of three national grants, two from CIHR supporting the research in cochlear gene therapy and relationship between hearing loss and cognitive impairment, and one from NSERC on the physiology of ribbon synapses in cochlea. He is also involved in collaborative research with two institutes in China and holds 3 research grants there as co-PI.

Education

  • BSc, Physiology, Nanjiing Medical College
  • MA, Physiology, Southeast University of Nanjing
  • MA, Audiology, State University of New York at Buffalo
  • PhD, Hearing Sciences, State University of New York at Buffalo

Research interests     

  • Ototoxicity and noise-induced hearing loss
  • Cochlear gene therapy
  • Auditory coding and plasticity
  • Impact of hearing loss on cognitive function

Teaching 

  • CMSD 6310: Audition I 
  • CMSD 5280: Audition II
  • CMSD 6070: Topics in Audiology Procedures
  • CMSD 6440: Noise in Industry and the Community

Selected publications

  • Chen, H., Xing, Y., Zhang, Z., Tao, S., Wang, H., Aiken, S., Yin, S., Yu, D., Wang, J. 2019. Coding-in-Noise Deficits are Not Seen in Responses to Amplitude Modulation in Subjects with cochlear Synaptopathy Induced by a Single Noise Exposure. Neuroscience 400, 62-71.
  • Chen, H., Xing, Y., Xia, L., Chen, Z., Yin, S., Wang, J. 2018. AAV-mediated NT-3 overexpression protects cochleae against noise-induced synaptopathy. Gene Ther 25, 251-259.
  • Chen, H., Shi, L., Liu, L., Yin, S., Aiken, S., Wang, J. 2018. Noise-induced Cochlear Synaptopathy and Signal Processing Disorders. Neuroscience.
  • Liu, L., Xuan, C., Shen, P., He, T., Chang, Y., Shi, L., Tao, S., Yu, Z., Brown, R.E., Wang, J. 2018. Hippocampal Mechanisms Underlying Impairment in Spatial Learning Long After Establishment of Noise-Induced Hearing Loss in CBA Mice. Front Syst Neurosci 12, 35.
  • Liu, L., Huang, Y., Fang, C., Zhang, H., Yang, J., Xuan, C., Wang, F., Lu, H., Cao, S., Wang, Y., Li, S., Sha, J., Zha, M., Guo, M., Wang, J. 2018. Chronic noise-exposure exacerbates insulin resistance and promotes the manifestations of the type 2 diabetes in a high-fat diet mouse model. PLoS One 13, e0195411.
  • O'Leary, T.P., Shin, S., Fertan, E., Dingle, R.N., Almuklass, A., Gunn, R.K., Yu, Z., Wang, J., Brown, R.E. 2017. Reduced acoustic startle response and peripheral hearing loss in the 5xFAD mouse model of Alzheimer's disease. Genes, brain, and behavior.
  • Pan, H., Song, Q., Huang, Y., Wang, J., Chai, R., Yin, S., Wang, J. 2017. Auditory Neuropathy after Damage to Cochlear Spiral Ganglion Neurons in Mice Resulting from Conditional Expression of Diphtheria Toxin Receptors. Scientific reports 7, 6409.
  • Guan, J., Yi, H., Zou, J., Meng, L., Tang, X., Zhu, H., Yu, D., Zhou, H., Su, K., Yang, M., Chen, H., Shi, Y., Wang, Y., Wang, J., Yin, S., Shanghai Sleep Health Study Research, G. 2016. Distinct severity stages of obstructive sleep apnoea are correlated with unique dyslipidaemia: large-scale observational study. Thorax 71, 347-55.
  • Liu, L., Shen, P., He, T., Chang, Y., Shi, L., Tao, S., Li, X., Xun, Q., Guo, X., Yu, Z., Wang, J. 2016. Noise induced hearing loss impairs spatial learning/memory and hippocampal neurogenesis in mice. Scientific reports 6, 20374.
  • Liu, L., Wang, F., Lu, H., Cao, S., Du, Z., Wang, Y., Feng, X., Gao, Y., Zha, M., Guo, M., Sun, Z., Wang, J. 2016. Effects of Noise Exposure on Systemic and Tissue-Level Markers of Glucose Homeostasis and Insulin Resistance in Male Mice. Environ Health Perspect 124, 1390-8.
  • Salvi, R., Sun, W., Ding, D., Chen, G.D., Lobarinas, E., Wang, J., Radziwon, K., Auerbach, B.D. 2016. Inner Hair Cell Loss Disrupts Hearing and Cochlear Function Leading to Sensory Deprivation and Enhanced Central Auditory Gain. Front Neurosci 10, 621.
  • Shi, L., Chang, Y., Li, X., Aiken, S., Wang, J. 2016. Cochlear Synaptopathy and Noise-induced Hidden Hearing Loss. Neural plasticity 2016.
  • Shi, L., Chang, Y., Li, X., Aiken, S.J., Liu, L., Wang, J. 2016. Coding Deficits in Noise-Induced Hidden Hearing Loss May Stem from Incomplete Repair of Ribbon Synapses in the Cochlea. Front Neurosci 10, 231.
  • Song, Q., Shen, P., Li, X., Shi, L., Liu, L., Wang, J., Yu, Z., Stephen, K., Aiken, S., Yin, S., Wang, J. 2016. Coding deficits in hidden hearing loss induced by noise: the nature and impacts. Scientific reports 6, 25200.
  • Zhang, G.Y., Yang, M., Liu, B., Huang, Z.C., Li, J., Chen, J.Y., Chen, H., Zhang, P.P., Liu, L.J., Wang, J., Teng, G.J. 2016. Changes of the directional brain networks related with brain plasticity in patients with long-term unilateral sensorineural hearing loss. Neuroscience 313, 149-61.\Jie, H., Tao, S., Liu, L., Xia, L., Charko, A., Yu, Z., Bance, M., Yin, S., Robertson, G.S., Wang, J. 2015. Cochlear protection against cisplatin by viral transfection of X-linked inhibitor of apoptosis protein across round window membrane. Gene Ther 22, 546-52.
  • Jie, H., Tao, S., Liu, L., Xia, L., Charko, A., Yu, Z., Bance, M., Yin, S., Robertson, G.S., Wang, J. 2015. Cochlear protection against cisplatin by viral transfection of X-linked inhibitor of apoptosis protein across round window membrane. Gene Ther 22, 546-52.
  • Chen, Y.C., Zhang, J., Li, X.W., Xia, W., Feng, X., Qian, C., Yang, X.Y., Lu, C.Q., Wang, J., Salvi, R., Teng, G.J. 2015. Altered intra- and interregional synchronization in resting-state cerebral networks associated with chronic tinnitus. Neural plasticity 2015, 475382.
  • Chen, Y.C., Xia, W., Feng, Y., Li, X., Zhang, J., Feng, X., Wang, C.X., Cai, Y., Wang, J., Salvi, R., Teng, G.J. 2015. Altered interhemispheric functional coordination in chronic tinnitus patients. BioMed research international 2015, 345647.
  • Chen, Y.C., Li, X., Liu, L., Wang, J., Lu, C.Q., Yang, M., Jiao, Y., Zang, F.C., Radziwon, K., Chen, G.D., Sun, W., Krishnan Muthaiah, V.P., Salvi, R., Teng, G.J. 2015. Tinnitus and hyperacusis involve hyperactivity and enhanced connectivity in auditory-limbic-arousal-cerebellar network. eLife 4, e06576.
  • Chen, Y.C., Xia, W., Luo, B., Muthaiah, V.P., Xiong, Z., Zhang, J., Wang, J., Salvi, R., Teng, G.J. 2015. Frequency-specific alternations in the amplitude of low-frequency fluctuations in chronic tinnitus. Front Neural Circuits 9, 67.
  • Wang, J., Song, Q., Yu, D., Yang, G., Xia, L., Su, K., Shi, H., Wang, J., Yin, S. 2015. Ontogenetic development of the auditory sensory organ in zebrafish (Danio rerio): changes in hearing sensitivity and related morphology. Scientific reports 5, 15943.
  • Zhang, J., Chen, Y.C., Feng, X., Yang, M., Liu, B., Qian, C., Wang, J., Salvi, R., Teng, G.J. 2015. Impairments of thalamic resting-state functional connectivity in patients with chronic tinnitus. European journal of radiology.
  • Zhang, G.Y., Yang, M., Liu, B., Huang, Z.C., Chen, H., Zhang, P.P., Li, J., Chen, J.Y., Liu, L.J., Wang, J., Teng, G.J. 2015. Changes in the default mode networks of individuals with long-term unilateral sensorineural hearing loss. Neuroscience 285, 333-42.
  • Xia, L., Chen, Z., Su, K., Yin, S., Wang, J. 2014. Comparison of cochlear cell death caused by cisplatin, alone and in combination with furosemide. Toxicol Pathol 42, 376-85.
  • Ruan, Q., Ao, H., He, J., Chen, Z., Yu, Z., Zhang, R., Wang, J., Yin, S. 2014. Topographic and quantitative evaluation of gentamicin-induced damage to peripheral innervation of mouse cochleae. Neurotoxicology 40, 86-96.
  • Ruan, Q., Zeng, S., Liu, A., Chen, Z., Yu, Z., Zhang, R., He, J., Bance, M., Robertson, G., Yin, S., Wang, J. 2014. Overexpression of X-Linked Inhibitor of Apoptotic Protein (XIAP) reduces age-related neuronal degeneration in the mouse cochlea. Gene Ther 21, 967-74.
  • Sun, S., Sun, M., Zhang, Y., Cheng, C., Waqas, M., Yu, H., He, Y., Xu, B., Wang, L., Wang, J., Yin, S., Chai, R., Li, H. 2014. In vivo overexpression of X-linked inhibitor of apoptosis protein protects against neomycin-induced hair cell loss in the apical turn of the cochlea during the ototoxic-sensitive period. Front Cell Neurosci 8, 248.
  • Chen, Y.C., Zhang, J., Li, X.W., Xia, W., Feng, X., Gao, B., Ju, S.H., Wang, J., Salvi, R., Teng, G.J. 2014. Aberrant spontaneous brain activity in chronic tinnitus patients revealed by resting-state functional MRI. NeuroImage. Clinical 6, 222-8.