Professor, Faculty of Dentistry, School of Biomedical Engineering
Mark Filiaggi, PhD
Cross-Appointments in SBME, Department of Radiology
Affiliated Scientist, Department of Diagnostic Imaging
QEII Health Sciences Centre
My core research program is founded on developing novel and potentially multifunctional biomaterials for medical devices, with a focus on those intended for bone-interfacing and cardiovascular applications. At the heart of this program is a desire to use sound materials science engineering principles and unique processing strategies to optimize the biological performance of materials destined for clinical applications. This approach is by necessity a multidisciplinary one, as it requires an additional working knowledge of cell behavior and biological processes along with substantial engagement with the clinical community.
Our research is focused on biomaterials and biomedical devices, with an emphasis on novel phosphate glass processing approaches that facilitate localized delivery of therapeutic agents, including antibiotics, anticancer drugs and therapeutic metal ions. Targeted clinical applications include osteomyelitis (chronic bone infection) and hepatocellular carcinoma (liver cancer). Further studies have examined surface modification strategies to enhance the osteopromotive and antimicrobial properties of metallic implants, including those used to support new dentition or dental restorations.
For these studies, we maintain active collaborations with both the basic science (Chemistry, Physics) and clinical (orthopaedics, intervention radiology) communities.
|PA Comeau and MJ Filiaggi, A two-stage cold isostatic pressing and gelling approach for fabricating a therapeutically loaded amorphous calcium polyphosphate local delivery system, Journal of Biomaterials Applications, 2017; 32(1): 126-136.|
|C Pierlot, L Kiri, K MacDonald, B Dickey, E Valiant, M Chagnon, M Assad, MJ Filiaggi, and D Boyd. A pilot evaluation of an aluminum-free glass ionomer cement using a sub-chronic osseous defect model in New Zealand white rabbits, Materials Letters 2016, 184:301-304.|
|EM Valliant, BT Dickey, R Price, D Boyd, and MJ Filiaggi. Fourier transform infrared spectroscopy as a tool to study the setting reaction in glass-ionomer cements, Materials Letters 2016, 185: 256-259.|
|R Pilliar, Y Hu, M Grynpas, R Kandel, U Werner-Zwanziger, M Filiaggi. Phase transformations during processing and in vitro degradation of porous calcium polyphosphates, Journal of Materials Science: Materials in Medicine 2016, 27:117.|
|A Momeni and MJ Filiaggi, Degradation and hemostatic properties of polyphosphate coacervates, Acta Biomaterialia 2016, 41: 328-341. doi:10.1016/j.actbio.2016.06.002|
|A Momeni, E Valliant, E Brennan-Pierce, J Shankar, R Abraham, P Colp, and M Filiaggi. Developing an in-situ forming polyphosphate coacervate as a new liquid embolic agent: from experimental design to pilot animal study, Acta Biomaterialia 2016, 32: 286-297.|
|A Momeni and M Filiaggi. Rheology of Polyphosphate Coacervates, Journal of Rheology 2016; 60(1): 25-34|
|PA Comeau and MJ Filiaggi. Structural Analysis of xSrO-(50-x)CaO-50P2O5 Glasses with x= 0 – 10 mol% for Potential Use in a Local Delivery System for Osteomyelitis Treatment. Materials Science & Engineering: Part C (Materials for Biological Applications) 2015; 58: 639-647.|
|L Kiri, M Filiaggi and D Boyd. Methotrexate-loaded glass ionomer cements for drug release in the skeleton: An examination of composition-property relationships, J Biomaterials Applications 2015; 30(6): 732-739.|
|P Comeau and MJ Filiaggi. Calcium Polyphosphate Precipitation - A strategy to tune the chain length of the glass and control the subsequent release of vancomycin. Materials Chemistry and Physics, June 2015; Volume 11: 56–63.|
|J. Daniel Padmos, Maxine Langman, Katelyn MacDonald, Patricia Comeau, Zhan Yang, Mark Filiaggi, and Peng Zhang; Correlating the Atomic Structure of Bimetallic Silver–Gold Nanoparticles to Their Antibacterial and Cytotoxic Activities, J. Phys. Chem. Part C 2015, 119 (13): 7472–7482.|
|EM Valliant, D Ganier, B Dickey, D Boyd, MJ Filiaggi, Calcium polyphosphate as an additive to zinc-silicate glass ionomer cements, Journal of Biomaterials Applications 2015; 30(1): 61-70. doi: 10.1177/0885328215568985|
|A Momeni and MJ Filiaggi, Comprehensive Study of the Chelation and Coacervation of Alkaline Earth Metals in the Presence of Sodium Polyphosphate Solution, Langmuir 2014; 30(18): 5256-66.|
|A Momeni and MJ Filiaggi, Synthesis and Characterization of Different Chain Length Sodium Polyphosphates, Journal of Non-Crystalline Solids 2013; 382 (15 December 2013): 11-17.|