Ian Weaver

Associate Professor

IWeaver

Email: Ian.Weaver@dal.ca
Phone: (902) 494-1133
Fax: (902) 494-6585
Mailing Address: 
Dalhousie University, Life Sciences Centre, 1355 Oxford Street, PO Box 15000, Halifax, NS B3H 4R2
 
Research Topics:
  • Brain and behaviour development and degeneration
  • Cancer stem cells and therapy resistance
  • Immuno-metabolism, DNA repaor and cell growth signalling
  • Molecular (epi)genetic mechanisms of gene regulation
  • Pharmacological and psycho-social interventions
  • Biomarker discovery

Education

BA (Aberdeen)
MSc (Bristol)
PhD (McGill)

Research Interests

Our multi-disciplinary research program focuses on molecular, metabolic, and immunological aspects of cellular and behavioural neuroscience, with a special focus on mechanisms of gene regulation. Current projects explore the potential role of chromatin remodeling genes, DNA methylation and DNA repair mechanisms in social, emotional and cognitive development. Additionally, our lab examines altered metabolism and gene regulatory networks in cancer and neurodegenerative disease.

Our research employs several state-of-the-art molecular, cellular, and behavioural assays to provide a complete picture of how experiences propagate from external to internal variables, and the role chromatin structure and remodelling genes play in neurobehavioural development.

Through cross-appointments with the Departments of Pathology and Psychiatry, and as a member of the Brain Repair Centre (www.brainrepair.ca) and the Atlantic Canada Chapter Chair for the Canadian Developmental Origins of Health and Disease Network (www.dohad.ca), my research group is well positioned to advance (epi)genetic profiling and integrative analysis of gene expression and regulation across a variety of animal and human tissues. We have also formed research partnerships with Canadian biotechnology and pharmaceuticals industry to further biomedical applications.

Interested in Joining Us?
WE ARE LOOKING FOR QUALIFIED GRADUATE STUDENTS AND POST-DOCTORAL FELLOWS. If you are interested in joining our research group, please send the following information to ian.weaver@dal.ca: 1. Your complete CV, 2. Research statement stating how your training matches our research goals and why you would like to join our team.

Selected Publications

·Huynh TT, Sultan M, Vidovic D, Dean CA, Cruickshank BM, Lee K, Loung CY, Holloway RW, Hoskin DW, Waisman DM, WEAVER ICG and Marcato P. 2019. Retinoic acid and arsenic trioxide induce lasting differentiation and demethylation of target genes in APL cells. Scientific Reports. Jul 1;9(1):9414.
·Fertan E, Rodrigues GJ, Wheeler RV, Goguen D, Wong AA, James H, Stadnyk A, Brown RE and WEAVER ICG. 2019. Cognitive decline, cerebral-spleen tryptophan metabolism, oxidative stress, cytokine production, and regulation of the txnip gene in a triple transgenic mouse model of Alzheimer disease. American Journal of Pathology. Jul;189(7):1435-1450.
·Connor KL, Bourque SL and WEAVER ICG. 2019. A Canadian perspective on the developmental origins of health and disease: Understanding the past as a way forward. Journal of Developmental Origins of Health and Disease. Feb;10(1):1-4.
·Sultan M, Vidovic D, Paine AS, Huynh TT, Coyle KM, Thomas ML, Cruickshank BM, Dean CA, Clements DR, Kim Y, Lee K, Gujar SA, WEAVER ICG and Marcato P. 2018. Epigenetic silencing of tap1 in aldefluor(+) breast cancer stem cells contributes to their enhanced immune evasion. Stem Cells. May;36(5):641-654.
·Sharif T, Martell E, Dai C, Ghassemi-Rad MS, Lee K, Singh SK, WEAVER ICG and Gujar S. 2018. Phosphoglycerate dehydrogenase inhibition induces p-mTOR-independent autophagy and promotes multilineage differentiation in embryonal carcinoma stem-like cells. Cell Death and Disease. Sep 24;9(10):990.
·Korgan AC, O'Leary E, King JL, WEAVER ICG and Perrot TS. 2018. Effects of paternal high-fat diet and rearing environment on maternal investment and development of defensive responses in the offspring. Psychoneuroendocrinology. May;91:20-30.
·Bydoun M, Sterea A, WEAVER ICG, Bharadwaj AD and Waisman DM. 2018. A novel mechanism of plasminogen activation in epithelial and mesenchymal cells. Scientific Reports. Sep 20;8(1):14091.
·Bydoun M, Sterea A, Liptay H, Uzans A, Huang WY, Rodrigues GJ, WEAVER ICG, Gu H and Waisman DM. 2018. S100A10, a novel biomarker in pancreatic ductal adenocarcinoma. Molecular Oncology. Nov;12(11):1895-1916.
·WEAVER ICG, Korgan AC, Lee K, Wheeler RV, Hundert AS and Goguen D. 2017. Stress and the emerging roles of chromatin remodeling in signal integration and stable transmission of reversible phenotypes. Frontiers in Behavioral Neuroscience. doi: 10.3389/fnbeh.2017.00041.
·Antony JM, WEAVER ICG, Rueffer M, Guthrie N and Evans M. 2017. The essentials of a global index for cognitive function. Translational Neuroscience. 8:87-96.
·Korgan AC, O'Leary E, Bauer J, Fortier A, WEAVER ICG and Perrot TS. 2016. Effects of paternal predation risk and rearing environment on maternal investment and development of defensive responses in the offspring. eNeuro. doi: 10.1523/ENEURO.0231-16.2016.
·Kennedy BE, Hundert AS, Goguen D, WEAVER ICG and Karten B. 2016. Presymptomatic alterations in amino acid metabolism and DNA methylation in the cerebellum of a murine model of niemann-pick type c disease. American Journal of Pathology. Jun;186(6):1582-1597.
·Coyle KM, Murphy JP, Vidovic D, Vaghar-Kashani A, Dean CA, Sultan M, Clements D, Wallace M, Thomas ML, Hundert A, Giacomantonio CA, Helyer L, Gujar SA, Lee PW, WEAVER ICG and Marcato P. 2016. Breast cancer subtype dictates DNA methylation and ALDH1A3-mediated expression of tumor suppressor RARRES1. Oncotarget. Jul 12;7(28):44096-44112.
·WEAVER ICG, Cervoni N, Champagne FA, D'Alessio AC, Sharma S, Seckl JR, Dymov S, Szyf M and Meaney MJ. 2004. Epigenetic programming by maternal behavior. Nature Neuroscience. Aug;7(8):847-854.

Applying for a Certificate in Genetics?

As a Certificate in Genetics Coordinator, I provide approval of the research component for applicants in the Psychology & Neuroscience Department and the Medical Sciences program. Please send your one-page honours research proposal to ian.weaver@dal.ca for review.