Phone: (902) 494-1133
Fax: (902) 494-6585
- Neurobehavioural epigenetic mechanisms
- Early life experience
- Steroid hormone function
- DNA and chromatin modification
- Programming of gene expression
- Cortical development
- Endocrine and behavioural stress responses
- Pharmacological interventions
- Psycho-social interventions
The role of DNA methylation and chromatin remodeling in mammalian development, with a life course perspective on neural adaptation and responses to stress and possible therapeutic and dietary intervention. Dr. Weaver’s research employs a wide range of techniques—e.g., bisulfite sequencing, ChIP analysis, RT-qPCR, ELISA, primary culture systems, epifluorescence microscopy and animal behaviour tracking—for the molecular, cellular and physiological evaluation of defensive systems (e.g., stress, immune and DNA damage pathways) underlying common human diseases, including autism spectrum disorder, metabolic syndrome, cancer and neurodegeneration. As a member of the Brain Repair Centre (www.brainrepair.ca) and the Atlantic Canada Chapter Chair for the Canadian Developmental Origins of Health and Disease Network (www.dohad.ca), his research group is well positioned for (epi)genetic profiling and integrative analysis of chromatin architecture across animal and human tissues.
•Weaver, I.C.G., Korgan, A., Lee, K., Wheeler, R., Hundert, A.S, & Goguen, D. 2017. Stress and the emerging roles of chromatin in signal integration and stable transmission of reversible phenotypes. Frontiers in Behavioral Neuroscience. March https://doi.org/10.3389/fnbeh.2017.00041 R. Hunter (Ed). Nature Publishing Group.
•Korgan, A.C., O’Leary, E., Bauer, J., Fortier, A., Weaver, I.C.G., & Perrot, T.S. 2016. Effects of paternal predation risk and rearing environment on maternal investment and development of defensive responses in the offspring. eNeuroscience, an affiliate of the Society for Neuroscience. Nov; 3(6) e0231- 16.2016: 1–14 (DOI: 10.1523/ENEURO.0231-16.2016)
•Coyle, K, M, Murphy, J.P, Vidovic, D., Vaghar-Kashani, A., Dean, C.A., Sultan, M., Clements, D., Wallace, M., Thomas, M.L., Hundert, A., Giacomantonio, C.A., Helyer, L., Gujar, S.A., Lee, P.W., Weaver, I.C.G., & Marcato, P. 2016. Breast cancer subtype dictates DNA methylation and ALDH1A3-mediated expression of tumor suppressor RARRES1. Oncotarget. Jul;7(28):44096-44112.
•Kennedy, B.E., Hundert, A.S., Goguen, D., Weaver, I.C.G., & Karten, B. 2016. Pre-symptomatic alterations in amino acid metabolism and DNA methylation in the cerebellum of a murine model of Niemann-Pick Type C disease. Am. J. Pathol. 186(4): 964–877. [*Co-CorA].
•Weaver, I.C.G., Hellstrom, I.C., Brown S.E., Andrews S.D., Dymov, S., Diorio, J., Zhang, T.Y., Szyf, M., & Meaney, M.J. 2014 The methylated-DNA binding protein MBD2 enhances NGFI-A (egr-1)-mediated transcriptional activation of the glucocorticoid receptor. Philosophical Transactions of the Royal Society B. Aug; 369(1652): 1-11.
•Weaver, I.C.G., Cervoni N., Champagne F.A., D’Alessio A.C., Sharma S., Seckl J.R., Dymov S., Szyf M., & Meaney M.J. 2004 Epigenetic programming by maternal behavior. Nature Neuroscience. Aug; 7(8): 847-54. Accompanied by a “News and Views” commentary (p791-2).