Zeeshan Sheikh, PhD
Dr. Zeeshan Sheikh is a Clinical Scientist in Periodontics, Assistant Professor-Tenure-Track in the departments of Applied Oral Sciences (AOS) and Dental Clinical Sciences (DCS) at the Faculty of Dentistry-Dalhousie University. Dr. Sheikh is a Fellow of The Royal College of Dentists of Canada (RCDC) in the field of Periodontics. Dr. Sheikh was trained as a dental clinician and a biomaterial scientist with clinical and research degrees of Dip.Dh, BDS, MSc, PhD and M.Perio in the fields of biomaterials research, clinical dentistry and surgical periodontics and implantology. He has more than 6 years of clinical experience in private and hospital-based dentistry. After graduating as a dentist, he worked as a dental surgeon for 2 years before proceeding to obtain an MSc degree in dental and biomaterials from Queen Mary, University of London (QMUL) with distinction. He obtained a PhD from McGill University, Faculty of Dentistry (2010-2014). He completed 2 Post-Doctoral Fellowships at Faculty of Dentistry, University of Toronto, The Mt. Sinai Hospital (Lunenfeld-Tanenbaum Research Institute) in Toronto, Canada and The Department of Laboratory Medicine and Pathology, Faculty of Medicine, University of Toronto (2015-2019). He completed his residency in Periodontics & Implant Surgery from Dalhousie University (2019-2022) and also obtained a Masters of Periodontics degree (M.Perio).
In addition to delivering several conference talks, presentations and CE courses both locally in Canada and internationally, Dr. Sheikh has several research publications, reviews, book chapters, case-reports and editorials in peer-reviewed and other journals. He has also co-edited three textbooks on Oral Biology and Dental Biomaterials. He is also the recipient of several research awards and prizes. Being trained extensively as a clinician scientist in institutions like the Baqai Medical University, Queen Mary University of London, McGill University, University of Toronto and Dalhousie University, his research expertise lies in developing novel biomaterial options for bone grafting and alveolar ridge augmentation applications. He has in the past and continues to collaborate extensively with industry and was recently the President of the CADR-NCOHR NSRG and was also the representative for Dalhousie University on the NCOHR communications committee. He is currently the Chair for the NCOHR-Knowledge Exchange Working Group.
Dr. Zeeshan Sheikh’s career is an amalgamation of the skills acquired during the MSc, PhD, Post-Doctoral training and Periodontics Specialty Training to allow the carrying out of funded collaborative translational research. Dr. Sheikh aims to continue working as a clinician-scientist in the fields of Periodontics and Biomaterials and become a contributing member of the academic community in Canada.
Dicalcium phosphate cements: Brushite and monetite. Faleh Tamimi, Zeeshan Sheikh, Jake Barralet. Acta Biomaterialia 8 (2012) 474–487
The effect of autoclaving on the physical and biological properties of dicalcium phosphate dihydrate bioceramics: brushite vs. monetite. Faleh Tamimi, Damien Le Nihouannen, Hazem Eimar, Zeeshan Sheikh, Svetlana Komarova, Jake Barralet. Acta Biomaterialia.2012 Aug; 8(8)
Reproducible quantification of osteoclastic activity: characterization of a biomimetic calcium phosphate assay. Salwa Maria, Christiane Prukner, Zeeshan Sheikh, Frank Mueller, Jake Barralet, Svetlana V Komarova. Journal of Biomedical Materials Research: Part B: Applied Biomaterials (2013)
Matrix metalloproteinases and their pathological upregulation in multiple sclerosis: an overview. Javaid, M.A, Abdallah, M.N., Ahmed, A.S. and Sheikh, Z Acta Neurol Belg DOI 10.1007/s13760-013-0239-x
Nociception and role of immune system in orofacial pain. Vivek Varma, Zeeshan Sheikh, Ahad Ahmed. Acta Neurol Belg. 2014: 1-8
Dental Biomaterials and a novel composite of zirconia and poly ether ether ketone for dental implants. Murali Ramamoorthi, Vivek Verma, Zeeshan Sheikh. IDJSR. January. 2015, volume 2
Oral antimicrobial peptides: Types and role in the oral cavity. Zohaib Khurshid, Mustafa Naseem, Zeeshan Sheikh, Shariq Najeeb, Sana Shahab, Sohail Zafar. Saudi Pharmaceutical Journal. March (2015) http://dx.doi.org/10.1016/j.jsps.2015.02.015
Characterization of biomimetic calcium phosphate labeled with fluorescent dextran for quantification of osteoclast activity, Salwa Maria, Christiane Prukner, Zeeshan Sheikh, Frank Mueller, Svetlana V Komarova, Jake Barralet. Acta Biomateralia. doi:10.1016/j.actbio.2015.03.026
Bone regeneration using bone morphogenetic proteins and various biomaterial carriers. Materials 2015, 8(4), 1778-1816; doi:10.3390/ma8041778. Zeeshan Sheikh, Mohammad Ahmad Javaid, Nader Hamdan, Raheel Hashmi
Chelate setting of alkali ion substituted calcium phosphates. Zeeshan Sheikh, Martha Geffers, Jake Barralet, Uwe Gbureck. Ceramics International. 2015 doi:10.1016/j.ceramint.2015.04.083
In vitro degradation and in vivo resorption of dicalcium phosphate cement based grafts.. Zeeshan Sheikh, Yu Ling Zhang, Liam Grover, Faleh Tamimi, Jake Barralet. ActaBiomaterialia. 2015 Doi:http://dx.doi.org/10.1016/j.actbio.2015.08.031
Biodegradable materials for bone repair and tissue engineering applications.. Zeeshan Sheikh, Sharique Najeeb, Zohaib Khurshid, Vivek Varma, Haroon Rashid, Michael Glogauer. Materials 2015, 8, 5744-5794; doi:10.3390/ma8095273
Macrophages and their interactions with implantable biomaterials.. Zeeshan Sheikh, Patricia Brooks, Oriyah Barzilay, Noah Fine, Michael Glogauer.. Materials 2015, 8(9), 5671-5701; doi:10.3390/ma8095269
Mechanisms of in vivo degradation and resorption of calcium phosphate based biomaterials.. Zeeshan Sheikh, Mohamed-Nur Abdallah, Ahmed Abdalla Hanafi, Syed Misbahuddin, Harron Rashid, Michael Glogauer. Materials 2015, 8(11), 7913-7925; doi:10.3390/ma8115430.
Surface modifications of dental implants by incorporation of roughness and hydroxyapatite coatings. Zeeshan Sheikh, Fahd Ahmed, Yuliya Mulyar, Sadaf Farookhi, Haroon Rashid, Vivek Varma, Murai Khalifa. JPDA, Vol. 24 No. 04 Oct-Dec 2015.
Protein Adsorption Capability on Polyurethane and Modified-Polyurethane Membrane for Periodontal Guided Tissue Regeneration Applications. Zeeshan Sheikh, Abdul Samad Khan, Nima Roohpour, Michael Glogauer, Ihtesham Rehman. Materials Science and Engineering C. Vol 68, 1st November 2016
Controlling Bone Graft Substitute Microstructure to Improve Bone Augmentation. Zeeshan Sheikh, Yu Ling Zhang, Justin Drager, M Nur Abdallah, Faleh Tamimi, Jake Barralet. Advanced Healthcare Materials. 19 May 2016. DOI: 10.1002/adhm.
Bifunctionality of Hypoxia Mimics in Bioceramic Bone Repair. Justin Drager, Zeeshan Sheikh, Yu Ling Zhang, Edward Harvey, Jake Barralet. Acta Biomaterialia, (42) 15 Sept, 2016 http://dx.doi.org/10.1016/j.actbio.2016.07.037
Collagen based barrier membranes for periodontal regeneration applications. Zeeshan Sheikh, Javairia Qureshi, M Al-Shahrani, Hiba Nasar, Yuichi Ikeda, Michael Glogauer, Bernhard Ganss. Odontology. September, 2016. DOI: 10.1007/s10266-016-0267-0
Effect of processing conditions of dicalcium phosphate cements on graft resorption and bone formation. Zeeshan Sheikh, Yu Ling Zhang, Faleh Tamimi, Jake Barralet. Acta Biomaterialia. February, 15th, 2017. http://dx.doi.org/10.1016/j.actbio.2017.02.022
Natural graft tissues and synthetic biomaterials for periodontal repair, regeneration and alveolar bone reconstructive applications: A review. Zeeshan Sheikh, Nader Hamdan, Yuichi Ikeda, Marc Grynpas, Bernhard Ganss, Michael Glogauer, Biomaterials Research. 2017 21:9. DOI: 10.1186/s40824-017-0095-5
Resveratrol derivative-rich melinjo seed extract induces healing in a murine model of established periodontitis. Yuichi Ikeda, Yongqiang Wang, Noah Fine, Zeeshan Sheikh, Oriyah Barzilay, Bernhard Ganss, Howard C Tenenbaum, Michael Glogauer. Journal of periodontology 89 (5), 586-595
Comparative adsorption profiles of basal lamina proteome and gingival cells onto dental and titanium surfaces. M Nur Abdallah, Ghada Abuelghanam, Zeeshan Sheikh, Simon Tran, Faleh Tamimi.. Acta biomaterialia 73, 547-558a 2018
Resolving Macrophages Counter Osteolysis by Anabolic Actions on Bone Cells. Ana Viniegra, Hailey Goldberg, Noah Fine, Zeeshan Sheikh, Marcelo Freire, Yongqiang Wang, Thomas E Van Dyke, Michael Glogauer and Corneliu Sima. Journal of dental research 97 (10), 1160-1169)
Improved Alveolar Ridge Augmentation Using Synthetic Monetite Based Onlay Grafts. Zeeshan Sheikh and Michael Glogauer. Oral Health Journal July 2018
A novel anabolic conjugate (C3) in the matrix of dicalcium phosphate onlay block grafts for achieving vertical bone augmentation: an experimental study on rabbit calvaria. Zeeshan Sheikh, Gang Chen, Marion Thevenin, Robert Young, Marc Grynpas, Michael Glogauer. Journal of oral and maxillofacial implants. DOI: 10.11607/jomi.7236
Differential response of human blood leukocytes to brushite, monetite and calcium polyphosphate biomaterials. Noah Fine*, Zeeshan Sheikh*, Faik Al Jaf, Morvarid Oveisi, Alon Borenstein, Youxin Hu, Robert Pilliar, Marc Grynpas, Michael Glogauer.*First authorship shared. Journal of Biomedical Materials Research: Part B - Applied Biomaterials. 22 April 2019 https://doi.org/10.1002/jbm.b.34385
A Novel Anabolic Conjugate (C3) in the Matrix of Dicalcium Phosphate Onlay Block Grafts for Achieving Vertical Bone Augmentation: An Experimental Study on Rabbit Calvaria.. Zeeshan Sheikh; Gang Chen; Thévenin, Marion; Young, Robert N.; Grynpas, Marc D.; Glogauer, Michael. International Journal of Oral & Maxillofacial Implants . Jul/Aug2019, Vol. 34 Issue 4, pe51-e63. 13p.
In Vivo Bone Effects of a Novel Bisphosphonate-EP4a Conjugate Drug (C3) for Reversing Postmenopausal Bone Loss in an Ovariectomized Rat Model. Zeeshan Sheikh, Gang Chen, Faik Al Jaf, Marion Thevenin, Kate Banks, Micheal Glogauer, Robert Young, Marc Grynpas. Journal of Bone and Mineral Research Plus. 16 September 2019 https://doi.org/10.1002/jbm4.10237
Achieving enhanced bone regeneration using monetite granules with bone anabolic drug conjugates (C3 and C6) in rat mandibular defects. Zeeshan Sheikh, Mohamed‐Nur Abdallah, Faik Al‐Jaf, Gang Chen, Nader Hamdan, Robert N Young, Marc D. Grynpas, Michael Glogauer. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 11 March 2020 https://doi.org/10.1002/jbm.b.34598
Improved bone regeneration using bone anabolic drug conjugates (C3 and C6) with deproteinized bovine bone mineral as a carrier in rat mandibular defects. Zeeshan Sheikh, Mohamed‐Nur Abdallah, Faik Al‐Jaf, Gang Chen, Nader Hamdan, Robert N Young, Marc D. Grynpas, Michael Glogauer. Journal of Periodontology. 25 February 2020 https://doi.org/10.1002/JPER.19-0645
Immune response to implanted bone replacement graft materials. Zeeshan Sheikh, Nader Hamdan, Haider Al-Waeli, Michael Glogauer. Oral Health Journal. 15th December, 2020