Alexander  Baker

Assistant Professor

Mailing Address: 
Department of Chemistry
Dalhousie University
6243 Alumni Crescent
P.O. Box 15000
Halifax NS B3H 4R2
Room 531
Research Topics:
  • Organic chemistry
  • Protein chemistry
  • Medicinal chemistry
  • Click chemistry
  • Synthetic biology
  • Chemical biology
  • Protein engineering
  • Enzyme catalysis
  • Enantioselective synthesis
  • Biomaterials


  • B.Sc: Dalhousie University
  • Ph.D.: University of Toronto (2019)
  • PDF: University of Toronto (2023)

Research Interests: 

The Baker Research Group focuses on chemical, gene engineering and synthetic biology tools to expand the repertoire of non-canonical amino acids available for protein synthesis applications in: 

  • Biomaterials: adhesives, hydrogels
  • Therapeutic proteins: anti-cancer, anti-bacterial
  • Enzymatic activity: engineered function

Please contact if you are interested in any of these topics and would like to discuss further. 

Selected Awards and Honours

  • NSERC Post-Doctoral Fellowship
  • MITACS Accelerate
  • University of Toronto Engineering Grads to Watch
  • University of Toronto Chemical Engineering Exhibition Research Poster 1st Place Health
  • Walter C. Sumner Memorial Fellowship
  • University of Toronto Chemical Engineering Student Life Catalyst Award
  • NSERC Alexander Graham Bell Canada Graduate Scholarship-Doctoral
  • NSERC Alexander Graham Bell Canada Graduate Scholarship-Master’s

Selected Publications

  • Baker, A.E.G.; Bahlmann, L.C.; Xue, C.; Lu, Y.H.; Cruickshank, J.; Cescon, D.W.; Shoichet, M.S. (2021) Chemically and mechanically defined hyaluronan hydrogels emulate the extracellular matrix for unbiased in vivo and in vitro organoid formation and drug testing in cancer. Materials Today. 56, 96-113
  • Baker, A.E.G.; Cui, H.; Ballios, B.G.; Ing, S.; Yan, P.; Wolfer, J.; Wright, T.; Dang, M.; Gan, N.Y.; Cooke, M.J.; Ortín-Martínez, A.; Wallace, V.A.; van der Kooy, D.; Devenyi, R.; Shoichet, M.S. (2021) Stable oxime-crosslinked hyaluronan-based hydrogel as a biomimetic vitreous substitute. Biomaterials 271 120750.
  • Baker, A.E.G.; Bahlmann, L.C.; Tam, R.Y.; Liu, J.C.; Ganesh, A.N.; Mitrousis, N.; Marcellus, R.; Spears, M.; Bartlett, J. M. S.; Cescon, D. W.; Bader, G.D.; Shoichet, M.S. (2019) Benchmarking to the Gold Standard: Hyaluronan-oxime Hydrogels Recapitulate Xenograft Models for In Vitro Breast Cancer Spheroid Culture. Adv Mater. 31, 1901166.
  • Baker, A.E.G.; Tam, R.Y.; Shoichet, M.S. (2017) Independently Tuning the Biochemical and Mechanical Properties of 3D Hyaluronan-based Hydrogels with Oxime and Diels-Alder Chemistry to Culture Breast Cancer Spheroids. Biomacromolecules. 18 (12), 4373-4384.