Department of Chemistry

Faculty of Science

Stephen L. Bearne

Professor

bearne_stephen

Related information

Department of Chemistry

Email: sbearne@dal.ca
Phone: 902-494-1974
Mailing Address: 
Department of Biochemistry & Molecular Biology
Dalhousie University
5850 College St.
PO Box 15000
Halifax, NS B3H 4R2
Canada
 
Research Topics:
  • Organic chemistry
  • Biological chemistry
  • Medicinal chemistry
  • Synthesis
  • Enzyme kinetics
  • Enzyme inhibitor design
  • Transition state stabilization
  • Protein structure and function


Education

  • BScH, Acadia University
  • PhD, University of Toronto,
  • MDCM, McGill University

Research interests

Our research focuses on understanding how protein-ligand interactions contribute to rate enhancements in enzymatic reactions, engineering new enzymes, developing tools for identification of specific enzymes in complex proteomes, and understanding the chemical mechanism of enzymes that are of therapeutic interest.

Selected awards and honours

  • Dalhousie Student Union Award for Teaching Excellence in the Faculty of Science, 2006

Selected publications

  • "A Paradigm for CH Bond Cleavage: Structural and Functional Aspects of Transition State Stabilization by Mandelate Racemase." S.L. Bearne and M. St. Maurice (Adv. Protein Chem. Struct. Biol., 2017, 109, 113-160).
  • "The Interdigitating Loop of the Enolase Superfamily as a Specificity Binding Determinant or 'Flying Buttress'." S.L. Bearne (Biochim. Biophys. Acta, 2017, 1865, 619-630).
  • "Exploring the Potent Inhibition of CTP Synthase by Gemcitabine-5'-Triphosphate." G.D. McCluskey, S. Mohamady, S.D. Taylor, and S.L. Bearne (ChemBioChem, 2016, 17, 2240-2249).
  • "Rational Design and Synthesis of Substrate-product Analogue Inhibitors of α-Methylacyl-coenzyme A Racemase from Mycobacterium tuberculosis." M. pal, M. Khanal, R. Marko, S. Thirumalairajan, and S.L. Bearne (Chem. Commun., 2016, 52, 2740-2743).
  • "An Additional Role for the Brønsted Acid-base Catalysts of Mandelate Racemase in Transition State Stabilization." M. Nagar, and S.L. Bearne (Biochemistry, 2015, 54, 6743-6752)