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Jan Rainey

Professor; Director, Nuclear Magnetic Resonance Research Resource (NMR3)

Department of Biochemistry and Molecular Biology , Department of Chemistry

Email: jan.rainey@dal.ca
Phone: 902-494-4632
Mailing Address: 
Department of Biochemistry & Molecular Biology
Dalhousie University
5850 College St., Room 9-B1
PO Box 15000
Halifax, NS B3H 4R2
Canada
 
Research Topics:
  • Physical chemistry
  • Biological chemistry
  • Computational chemistry
  • Spectroscopy
  • NMR spectroscopy
  • Scanning probe microscopy
  • Structural biology
  • Protein chemistry
  • Protein engineering


Education

  • BSc, University of Guelph
  • MSc, University of Toronto
  • PhD, University of Toronto
  • PDF, University of Alberta

Research interests

Our focus is characterization and tailoring of protein structure and function in environments such as cell membranes or supramolecular assemblies. NMR and optical spectroscopy are employed alongside single molecule methods, with computational methods developed to correlate data from disparate techniques.

Selected awards and honours

  • Canadian Institutes of Health Research New Investigator Award, 2012-2017
  • Natural Sciences and Engineering Research Council of Canada Postdoctoral Fellowship, 2004-2006
  • Alberta Heritage Foundation for Medical Research Postdoctoral Fellowship, 2003-2006
  • Natural Sciences and Engineering Research Council of Canada Postgraduate Scholarship, 2000-2002

Selected publications

  • “The Multifaceted Substrate Capture Scheme of a Rhomboid Protease.” T. Reddy, and Jan K. Rainey* (J. Phys. Chem. B, 2012, 116, 8942-8954).
  • “Improved Helix and Kink Characterization in Membrane Proteins Allows Evaluation of Kink Sequence Predictors.” D. N. Langelaan, M. Wieczorek, C. Blouin, and Jan K. Rainey* (J. Chem. Inf. Model., 2010, 50, 2213-2220).
  • “The Predictive Accuracy of Secondary Chemical Shifts is More Affected by Protein Secondary Structure than Solvent Environment.” M-L. Tremblay, A. W. Banks, and Jan K. Rainey* (J. Biomol. NMR., 2010, 46, 257-270).
  • “Headgroup-Dependent Membrane Catalysis of Apelin-Receptor Interactions is Likely.” D. N. Langelaan, and Jan K. Rainey* (J. Phys. Chem. B, 2009, 113, 10465-10471).
  • “Structural Insight into G-Protein Coupled Receptor Binding by Apelin.” D. N. Langelaan, E. M. Bebbington, T. Reddy, and Jan K. Rainey* (Biochemistry, 2009, 48, 537-548).