For some selected examples of our published work in the area of ancillary ligand design with applications in otherwise challenging nickel-catalyzed C-N/C-O cross-couplings of (hetero)aryl chlorides and beyond, please see:

CgPhen-DalPhos: ACS Catal. 2021, 11, 17, 10878–10884 (tertiary alcohols)

PhPAd-DalPhos: Angew. Chem. Int. Ed., 2020, 59, 8952-8956 (sulfonamides)

Phen-DalPhos: ACS Catal., 2019, 9, 9292-9297 (heteroaryl amines, ammonia, indole)

PAd2-DalPhos: Angew. Chem. Int. Ed., 2019, 58, 6391-6395 (heteroaryl amines)

PAd2-DalPhos: Angew. Chem. Int. Ed., 2021, 60, 4080-4084 (fluoroalkylamines)

PAd2-DalPhos: Angew. Chem. Int. Ed., 2022, 61, e202200352 (amides, mechanism)

PhPAd-DalPhos: Angew. Chem. Int. Ed., 2019, 58, 2485-2489 (bulky primary alkylamines)

NHP-DalPhos: ACS Catal., 2018, 8, 5328-5339 (primary alkylamines)

CyPAd-DalPhos: J. Am. Chem. Soc., 2018, 140, 5023-5027 (aliphatic alcohols)

CyPAd-DalPhos: ACS Catal., 2017, 7, 6048−6059 (cyclopropylamine and variants)

PAd-DalPhos: Chem. Eur. J., 2016, 22, 18752-18755 (primary amides and lactams)

PAd-DalPhos: Nature Comm. 2016, 7, 11073 (ammonia and primary alkylamines)

An interview with Mark regarding the development of DalPhos ligands and his being named an Arthur B. McDonald Research Chair can be found here. 

To listen to an interview with Mark on the podcast "Sciographies": 

https://soundcloud.com/sciographies/mark-stradiotto