Sodium Channels & Arthritis Pain

Sodium Channels

A subset of arthritis patients suffer from neuropathic pain arising from damage to joint nerves. Some of the main targets of these injured nerves are the voltage gated sodium channels NaV1.7 and NaV1.8.

The McDougall Lab has found that opening of NaV1.8 channels causes joint pain. We have shown that blocking NaV1.8 reduces joint pain, especially in females.