Spring 2021 Research Update

Research_update_pic

By Dr. Cheryl Kozey, Professor, School of PT Research Coordinator

Our School of Physiotherapy had many research successes to celebrate over the past months.

The School of Physiotherapy Research Committee was established to facilitate and promote research excellence and growth within the School. Its’ Terms of Reference were approved at our Faculty of the Whole Committee in January 2021 and the Committee members include Drs. Shaun Boe and Rebecca Moyer as the two faculty research members and I am the Research Coordinator and Chair of the Committee. The Committee will engage in five main activities to meet its goal and one key activity is to enhance communication related to research successes of School of Physiotherapy researchers, research trainees, and non-research students. Recognizing success is the fun part of this role – I am pleased to relay the abundance of successes over the past few months. I will highlight the collective success as the individual research outcomes are listed at the end of this column.

First, with respect to grant capture, we had nine grants awarded where researchers are both Principal and Co-applicants totalling just under $3.5M.  Funding sources include national grants from the Canadian Institutes for Health Research (CIHR) and the Natural Sciences and Engineering Research Council (NSERC) as well as regional and local grants. All are necessary to ensure that the research can be completed.  To compliment this funding, we have had two MSc Rehabilitation Research students who were awarded Canada Graduate Scholarships (CGS), an NSERC CGS to Cassidy Klein who is supervised by Dr. Boe and a CIHR CGS plus Nova Scotia Graduate Scholarship to Jack Quach who is co supervised by Drs. Kehler and Theou. Great news and congratulations to all! 

Importantly is that this research is being disseminated in a variety of ways including 15 peer-reviewed journal articles in highly appropriate journals for ageing, musculoskeletal and neurorehabilitation research. In addition, researchers have presented their work to international, national, and regional audiences including presentations to research communities that are important to advancing knowledge and changing thinking. As well, there have been educational presentations which are vital for mobilizing research evidence to inform knowledge users that can impact health practice and policy.  As mentioned above, the research of our students is pivotal to all aspects of our success. We had two successful thesis defences, one in the MSc Rehabilitation Research program (Anwaar Hariri) and the other in the PhD Neurosciences (Chris Friesen), both supervised by Dr. Boe.  Furthermore, a former student and post-doctoral trainee are in on the action with Dr. Eric Robitaille’s recent publication (below) based on his post-doctoral work with Dr. Alice Aiken and co-author Marsha MacRae, an alum of Dalhousie (PT’95).

Overall, we have had a pretty good start to 2021 on the research front and look forward to sharing the next update with you!

GRANTS

C MacArthur, P Ghanouni, L Shaw, C O’Keefe, C Hall, and J Karabanow – Awarded Dalhousie Mental Health Connections Pilot Mental Health Foundation of Nova Scotia - Community Grant competition. Total: $21,190.94

S Boe - Principal Investigator (May 2020 - April 2026) – Awarded Establishing the nature and processes of error-based learning via motor imagery Natural Sciences and Engineering Research Council of Canada (NSERC) Total: $279,018

L Shaw, D Pereira - Collaborators – Awarded Living Laboratory Grant Application Virtual Integrative IP Access (VIIA): Advancing medical and Interprofessional (IP) education through a Virtual Family Medicine (FM), Occupational Therapy and Physiotherapy. Department of Family Medicine. Total: $5,000.

C Kozey, R Moyer – Co Principal Investigators D Rutherford, O Theou -Co-Applicants - Awarded
2020 Dalhousie Medical Research Foundation Equipment Grant 
30K + 26K Matching funds from NSHA Total: $56,000.
Funding for the purchase of a GE Healthcare Logic P9 Ultrasound System

C McArthur, S Kehler, D Gonzalez, B Lee, O Theou, A Quigley – Awarded
Supporting Accurate and Meaningful Measurement of Adherence to Resistance and Balance Training Faculty of Health Development Grant Total: $5000.00
 
O Theou - Co-Applicant - Awarded
COVID-19 Immunity Task Force - COVID-19 Hot Spots, Immunity in LTCF residents at risk of COVID-19 disease and death: immune biomarkers, immune function, and frailty associated with clinical outcomes in COVID-19 pandemic waves 1 and 2. COVID-19 Immunity Task Force, Total: $1,614,022
 
A Papaioannou , …C McArthur , et al. The PREVENT trial: a pragmatic cluster randomized controlled trial of a multicomponent fracture prevention model for long-term care. CIHR Project Grant, April 2021-March 2024. $569,926.00

A Papaioannou …, McArthur C, et al. Getting Fit for Hip or Knee Replacement: The Fit Joints Randomized Controlled Trial of A Multimodal Intervention in Frail Patients with Osteoarthritis. CIHR Project Grant, April 2021-March 2025. $704,469.00

O Theou - Principal Investigator
Canadian Institute of Health Research, Operating Grant: Understanding the Health Impact of Inactivity, The impact of prolonged bed rest and exercise on frailty and frailty-related biological markers. CIHR Total: $199,974
 

PUBLICATIONS

Robitaille E, MacRae M, Rowe P, Aiken A. A knowledge translation intervention to promote evidence-based practices in ankle sprain management among Canadian Armed Forces physiotherapists: six-month results. Journal of Military, Veteran and Family Health. 2021 Feb 1;7(1):46-54. 

Edwards J, Black S, Boe S, Boyd L, Chaves A, Chen R, Dukelow S, Fung J, Kirton A, Meltzer J, Moussavi Z, Neva J, Paquette C, Ploughman M, Pooyania S, Rajji T, Roig M, Tremblay F, Theil A. Canadian platform for trials in non-invasive brain stimulation (CanStim) consensus recommendations for repetitive transcranial magnetic stimulation in upper extremity motor stroke rehabilitation trials. Neurorehabilitation and Neural Repair, 2021; 35(2), 103-116. Read the complete article (PDF).

Jayanama K, Theou O, Godin J, Cahill L, Shivappa N, Hébert JR, Wirth MD, Park Y-M, Fung TT, Rockwood K (2021). Relationship between diet quality scores and the risk of frailty and mortality in adults across a wide age spectrum. BMC Medicine, 19(1), 64. www.pubfacts.com/author/Olga+Theou

Thompson MQ, Theou O, Ratcliffe J, Tucker GR, Adams RJ, Walters SJ, Visvanathan R (2021). Frailty state utility and minimally important difference: Findings from the North West Adelaide Health Study. Age and Ageing, 50(2), 565-569.

Pérez Zepeda MU, Godin J, Armstrong JJ, Andrew MK, Mitnitski A, Kirkland S, Rockwood K, Theou O (2021). Frailty among middle-aged and older Canadians: Population Norms for the Frailty Index using the Canadian Longitudinal Study on Aging. Age Ageing, 50(2), 447-456.
 
Lee JW, Kraeutner SN, Pancura DR, Boe SG. Probing the effect of block duration on corticospinal excitability during motor imagery performance. Journal of Motor Behavior, 2021; 53(3), 316-323.

Blodgett JM, Rockwood K, Theou O (2021). Changes in the severity and lethality of age-related health deficit accumulation in the USA between 1999 and 2018: a population-based cohort study. The Lancet Healthy Longevity, 2(2), 96-104.

Thompson MQ, Yu S, Tucker GR, Adams RJ, Cesari M, Theou O, Visvanathan R (2021). Frailty and sarcopenia in combination are more predictive of mortality than either condition alone. Maturitas, 144, 102-107

McArthur C, Ioannidis G, Jantzi M, Adachi JD, Giangregorio L, Hirdes J, Papaioannou A. (2021) Validation of the Fracture Risk Scale Home Care (FRS-HC) across four Canadian provinces. Journal of the American Medical Director’s Association. S1525-8610(21)00114-6. doi: 10.1016/j.jamda.2021.01.064

Thompson MQ, Theou O, Tucker GR, Adams RJ, Visvanathan R (2020). FRAIL scale: predictive validity and diagnostic test accuracy. Australasian Journal on Ageing, 39(4):e529-e536.

Fenwick P, Colborne A, Theou O, Cahill L (2020). Medical students’ perceptions of nutrition in medical education and future practice. Dalhousie Medical Journal, 47 (1), 23-30.

Wallace L, Theou O, Darvesh S, Bennett D, Buchman A, Andrew M, Kirkland S, Fisk J, Rockwood K (2020). Neuropathological burden and the degree of frailty in relation to global cognition and dementia. Neurology, 95(24), e3269-e3279.

Salbach NM, MacKay-Lyons M, Solomon S, Howe J, McDonald A, Brooks D, Bayley M, Veitch S, Mihailidis A. The role of theory to develop and evaluate a toolkit to increase clinical measurement and interpretation of walking speed and distance in adults post-stroke. Disability and Rehabilitation DOI: 10.1080/09638288.2020.1867653.

Kraeutner SN, McArthur JL, Kraeutner PH, Westwood DA, Boe SG. Leveraging the effector independent nature of motor imagery when it is paired with physical practice. Scientific Reports, 2020 10: 21335. Read the complete article (PDF).

Outerleys JB, Dunbar MJ, Richardson G, Hubley-Kozey CL, Astephen Wilson JL. Quantifying Achievable Levels of Improvement in Knee Joint Biomechanics During Gait After Total Knee Arthroplasty Relative to Osteoarthritis Severity. J Appl Biomech. 2021 Jan 15;37(2):130-138. doi: 10.1123/jab.2020-0051. PMID: 33450729.

Hatfield GL, Costello KE, Astephen Wilson JL, Stanish WD, Hubley-Kozey CL. Baseline Gait Muscle Activation Patterns Differ for Osteoarthritis Patients Who Undergo Total Knee Arthroplasty Five to Eight Years Later From Those Who Do Not. Arthritis Care Res (Hoboken). 2021 Apr;73(4):549-558. doi: 10.1002/acr.24143. PMID: 31961496.

*Schrijvers J, Rutherford D, Richards R, van den Noort J, van der Esch M, Harlaar J, Inter-laboratory comparison of knee biomechanics and muscle activation patterns during gait in patients with knee osteoarthritis, The Knee (March 2021) In press.

 

MEDIA

O Theou 2021, Government of Canada invests in first‑of‑its‑kind research study on the health impacts of inactivity
https://www.dal.ca/news/2021/02/25/government-of-canada-invests-in-first-of-its-kind-research-study.html

PRESENTATIONS

C.L Hubley-Kozey: Invited OARSI Live Hour (Feb 3, 2021) Session Title: Walk this way: Insights into knee osteoarthritis from gait mechanics. Presentation title: Longitudinal changes in knee joint GAIT mechanics and muscle activation patterns in individuals with medial compartment knee osteoarthritis. Co-authors: WD Stanish, N Urquhart, DM Ikeda, J Astephen Wilson

R. Moyer-Invited-OARSI Live Hour (Feb 3, 2021) Session Title: Walk this way: Insights into knee osteoarthritis from gait mechanics: Talk Title: Changes in Medial Compartment Loading and Articular Cartilage Thickness 24 Months After Limb Realignment Surgery in the Operative and Non-operative Limbs

R. Moyer -GLA:D Workshop (March 6-7, 2021) Virtual delivery across Canada

C McArthur Embodia Webinar Series – co-presenter. “Dementia for Rehabilitation Professionals.” March 3, 17, and 31, 2021. https://www.embodiaapp.com/webinars/410-dementia-and-rehabilitation-the-long-term-care-edition-deborah-hawkins-caitlin-mcarthur

C McArthur North Simcoe Muskoka Specialized Geriatric Services education session. “Minimizing the Risk of Fracture in Long-term Care”. March 10, 2021.

C McArthur YMCA LiveWell@Home Online Education Series. “What are the best exercises to prevent falls?” February 5, 2021.

M MacKay Lyons Virtual Care in Stroke Rehabilitation: Lessons Learned from COVID-19. Plenary Session. Atlantic Stroke Virtual Conference, Jan, 2021

M MacKay Lyons Telerehabilitation for Stroke Care Beyond COVID-19: Evidence of Effectiveness and Practical Tips for Successful Implementation. Invited. Atlantic Stroke Virtual Conference, Jan, 2021

STUDENT SCHOLARSHIPS

Cassidy Klein - MSc Rehabilitation Research (supervisor Dr. Boe) NSERC Canada Graduate Scholarship Total: $17,500 - one year

Jack Quach - MSc Rehabilitation Research (co-supervisor Drs. Kehler and Theou) CIHR CGS Canada Graduate Scholarship Total: $17,500 - one year NSGS: $10,000/year for two years.