More Publications

Selected Recent Refereed Journal Publications

• Gunathilake, K.D.P.P., K.K.D.S. Ranaweera, and H.P.V. Rupasinghe. 2017. Response surface optimization of phenolics and carotenoids extraction from leaves of Olax zeylanicaAnnals. Food Science and Technology. 18:337-342.

• Gunathilake, K.D.P.P., K.K.D.S. Ranaweera, H.P.V. Rupasinghe, O.D.A.N. Perera, and H.P.S. Jayaweera. 2017. Response surface optimization of extraction of polyphenols and carotenoids from Sesbania grandiflora leaves with ethanol-water system. Asian Journal of Biotechnology and Bioresource Technology. 2:1-10.

• Arumuggam, N., N. Melong, C.L.K. Too, J.N. Berman, H.P.V. Rupasinghe. 2017. Phloridzin docosahexaenoate, a novel flavonoid derivative, suppresses growth and induces apoptosis in T-cell acute lympholastic leukemia cells. American Journal of Cancer Research. 7:2452-2464.

• George, V.C., H.P.V. Rupasinghe. 2017. Apple flavonoids suppress carcinogens-induced DNA damage in normal human bronchial epithelial cells. Oxidative Medicine and Cellular Longevity. 2017: Article ID 1767198, 12 pages.

• Xu, Z., R. Peng, X. Chen, R. Ghosh, H.P.V. Rupasinghe. 2017. Isolation of flavonoids from apple peel using novel graphene oxide cotton fiber. Natural Product Research. 31(21):2559-2563.

• Wijesundara, N., H.P.V. Rupasinghe. 2017. Phytochemical-rich medicinal plant extracts suppress bacterial antigens-induced inflammation in human tonsil epithelial cells. PeerJ. 5:e3469.

• Zhang, B., L. Abbey, and H.P.V. Rupasinghe. 2017. Growing medium amendments effect on growth, secondary metabolites and anti-streptococcal activity of two species of PlectranthusJournal of Applied Research on Medicinal and Aromatic Plants. 5:53-59.

• Gunathilake, K.D.P.P. and H.P.V. Rupasinghe. 2017. Optimization of phenolics and carotenoids extraction from leaves of Passiflora edulis using response surface methods. Asian Journal of Biotechnology and Bioresource Technology. 1:1-11.

• George, V.C., G. Dellaire, H.P.V. Rupasinghe. 2017. Plant flavonoids in cancer chemoprevention: Role in genome stability. The Journal of Nutritional Biochemistry. 45:1-14.

• Jiang, Y., L. Zhang, H.P.V. Rupasinghe. 2017. Antiproliferative effects of extracts from Salvia officinalis L. and Salivia miltiorrhiza Bunge on hepatocellular carcinoma cells.Biomedicine & Pharmacotheraphy. 85:57-67.

• Fernando, W., M.R. Power-Coombs, D.W. Hoskin, H.P.V. Rupasinghe. 2016. Docosahexaenoic acid acylated-phloridzin, a novel polyphenol fatty acid ester derivative, is cytotoxic to breast cancer cells. Carcinogenesis 37:1004-1013.

• Parmar, I., S.V. Nair, H.P.V. Rupasinghe. 2016. Polyphenol characterization, anti-oxidant, anti-proliferation and anti-tyrosinase activity of cranberry pomace. Functional Foods in Health and Disease. 6:754-768.

• George, V.C, V.V. Vijesh, D.I.M. Amarararathna, C.A. Lakshmi, K. Anbarasu, D.R.N. Kumar, K.R. Ethiraj, R.A. Kumar, and H.P.V. Rupasinghe. 2016. Mechanism of action of flavonoids in prevention of inflammation-associated skin cancer. Current Medicinal Chemistry 23:1-20.

• Amararathna, M., M.R. Johnston, H.P.V. Rupasinghe. 2016. Plant polyphenols as chemopreventive agents for lung cancer. International Journal of Molecular Sciences. 17:1352-1366.

 Rupasinghe, H.P.V., S. Sekhon-Loodu, T. Mantso, M.I. Panayiotidis. 2016. Phytochemicals in regulating fatty acid β-oxidation: Potential underlying mechanisms and their involvement in obesity and weight loss. Pharmacology & Therapeutics. 165:153-163.

• Warnakulasuriya, S.N., Ziaullah, and H.P.V. Rupasinghe. 2016. Novel long chain fatty acid derivatives of quercetin-3-O-glucoside reduce cytotoxicity induced by cigarette smoke toxicants in human fetal lung fibroblasts. European Journal of Pharmacology. 781:128-138.

• Warnakulasuriya, S.N., Ziaullah, and H.P.V. Rupasinghe. 2016. Long chain fatty acid esters of quercetin-3-O-glucoside attenuate H2O2-induced acute cytotoxicity in human lung fibroblasts and primary hepatocytes. Molecules. 21:452-471.

• Jiang, Y., L. Zhang, H.P.V. Rupasinghe. 2016. The anticancer properties of phytochemical extracts from Salvia plants. Botanics: Targets and Theraphy. 6:25-44.

• Abachi, S., S. Lee and H.P.V. Rupasinghe. 2016. Molecular mechanisms of inhibition of streptococcus species by phytochemicals. Molecules. 21:215-246.

• Ziaullah and H.P.V. Rupasinghe. 2016. Sonochemical enzyme-catalyzed regioselective acylation of flavonoid glycosides. Bioorganic Chemistry. 65:17-25.

• Duffield, K.M., M.R. Ness, K.S. Bhullar, H.P.V. Rupasinghe, J. Balzarini, A. Jha. 2015.  Curcumin-inspired cytotoxic 3,5-bis(arylmethylene)-1-(N-arylmaleamoyl)-4-piperidones: A novel group of topoisomerase II alpha inhibitors. Bioorganic & Medicinal Chemistry. 23:6404-6417.

• Bhullar, K.S. and H.P.V. Rupasinghe. 2015. Partridgeberry polyphenols protect primary cortical and hippocampal neurons against β-amyloid toxicity. Food Research International. 74: 237–249.

• Arumuggam, N., N.A. Bhowmick, H.P.V. Rupasinghe. 2015. Phytochemicals targeting JAK/STAT signaling and IDO expression in cancer. Phytotheraphy Research. 29:805-817.

• Sekhon-Loodu, S. Ziaullah, and H.P.V. Rupasinghe. 2015. Docosahexaenoic acid ester of phlorizin inhibit lipopolysaccharide-induced inflammation in THP-1 differentiated macrophages. International Immunopharmacology. 25:199-206.

• Caseya, S.C., A. Amedei, K. Aquilano, A.S. Azmi, F. Benencia, D. Bhakta, A.E. Bilsland, C.S. Boosani, S. Chen, M.R. Ciriolo, S. Crawford, H. Fujii, A.G. Georgakilas, G. Guha, D. Halicka, W.G. Helferich, P. Heneberg, K. Honoki, W.N. Keith, S.P. Kerkar, S.I. Mohammed, E. Niccolai, S. Nowsheen, H.P.V. Rupasinghe, A. Samadi, N. Singh, W.H. Talib, V. Venkateswaran, R.L. Whelan, and X. Yang. 2015. Cancer prevention and therapy through the modulation of the tumor microenvironment – A review. Seminars in Cancer Biology. 35:S199-S223.

• Bhullar, K.B., A. Jha, and H.P.V. Rupasinghe. 2015. Novel carbocyclic curcumin analog CUR3d modulates genes involved in multiple apoptosis pathways in human hepatocellular carcinoma cells. Chemico-Biological Interactions. 242:107-122.

• Potter, E., M. Jha, K. Bhullar, H.P.V. Rupasinghe, J. Balzarini, and A. Jha. 2015. Investigation of fatty acid conjugates of 3,5-bisarylmethylene-4-piperidone derivatives as antitumor agents and human topoisomerase-IIα inhibitors. Journal of Bioorganic Chemistry. 23:411-421.

• Bhullar, K.B. and H.P.V. Rupasinghe. 2015. Antioxidant and cytoprotective properties of partridgeberry polyphenols. Food Chemistry. 168:595-605.

• Sekhon-Loodu, S., Ziaullah, H.P.V. Rupasinghe, Y. Wang, M. Kulka, and F. Shahidi. 2015. Novel quercetin-3-O-glucoside eicosapentaenoic acid ester ameliorates inflammation and hyperlipidemia. Inflammopharmacology. 23:173-185.

• Warnakulasuriya, S.N., Ziaullah, and H.P.V. Rupasinghe. 2016. Novel long chain fatty acid derivatives of quercetin-3-O-glucoside reduce cytotoxicity induced by cigarette smoke toxicants in human fetal lung fibroblasts. European Journal of Pharmacology. 781:128-138.

• Warnakulasuriya, S.N., Ziaullah, and H.P.V. Rupasinghe. 2016. Long chain fatty acid esters of quercetin-3-O-glucoside attenuate H2O2-induced acute cytotoxicity in human lung fibroblasts and primary hepatocytes. Molecules. 21:452-471.

• Jiang, Y., L. Zhang, H.P.V. Rupasinghe. 2016. The anticancer properties of phytochemical extracts from Salvia plants. Botanics: Targets and Theraphy. 6:25-44.

• Abachi, S., S. Lee and H.P.V. Rupasinghe. 2016. Molecular mechanisms of inhibition of streptococcus species by phytochemicals. Molecules. 21:215-246.

• Ziaullah and H.P.V. Rupasinghe. 2016. Sonochemical enzyme-catalyzed regioselective acylation of flavonoid glycosides. Bioorganic Chemistry. 65:17-25.

• Duffield, K.M., M.R. Ness, K.S. Bhullar, H.P.V. Rupasinghe, J. Balzarini, A. Jha. 2015.  Curcumin-inspired cytotoxic 3,5-bis(arylmethylene)-1-(N-arylmaleamoyl)-4-piperidones: A novel group of topoisomerase II alpha inhibitors. Bioorganic & Medicinal Chemistry. 23:6404-6417.

• Bhullar, K.S. and H.P.V. Rupasinghe. 2015. Partridgeberry polyphenols protect primary cortical and hippocampal neurons against β-amyloid toxicity. Food Research International. 74: 237–249.

• Arumuggam, N., N.A. Bhowmick, H.P.V. Rupasinghe. 2015. Phytochemicals targeting JAK/STAT signaling and IDO expression in cancer. Phytotheraphy Research. 29:805-817.

• Sekhon-Loodu, S. Ziaullah, and H.P.V. Rupasinghe. 2015. Docosahexaenoic acid ester of phlorizin inhibit lipopolysaccharide-induced inflammation in THP-1 differentiated macrophages. International Immunopharmacology. 25:199-206.

• Caseya, S.C., A. Amedei, K. Aquilano, A.S. Azmi, F. Benencia, D. Bhakta, A.E. Bilsland, C.S. Boosani, S. Chen, M.R. Ciriolo, S. Crawford, H. Fujii, A.G. Georgakilas, G. Guha, D. Halicka, W.G. Helferich, P. Heneberg, K. Honoki, W.N. Keith, S.P. Kerkar, S.I. Mohammed, E. Niccolai, S. Nowsheen, H.P.V. Rupasinghe, A. Samadi, N. Singh, W.H. Talib, V. Venkateswaran, R.L. Whelan, and X. Yang. 2015. Cancer prevention and therapy through the modulation of the tumor microenvironment – A review. Seminars in Cancer Biology. 35:S199-S223.

• Bhullar, K.B., A. Jha, and H.P.V. Rupasinghe. 2015. Novel carbocyclic curcumin analog CUR3d modulates genes involved in multiple apoptosis pathways in human hepatocellular carcinoma cells. Chemico-Biological Interactions. 242:107-122.

• Potter, E., M. Jha, K. Bhullar, H.P.V. Rupasinghe, J. Balzarini, and A. Jha. 2015. Investigation of fatty acid conjugates of 3,5-bisarylmethylene-4-piperidone derivatives as antitumor agents and human topoisomerase-IIα inhibitors. Journal of Bioorganic Chemistry. 23:411-421.

• Bhullar, K.B. and H.P.V. Rupasinghe. 2015. Antioxidant and cytoprotective properties of partridgeberry polyphenols. Food Chemistry. 168:595-605.

• Sekhon-Loodu, S., Ziaullah, H.P.V. Rupasinghe, Y. Wang, M. Kulka, and F. Shahidi. 2015. Novel quercetin-3-O-glucoside eicosapentaenoic acid ester ameliorates inflammation and hyperlipidemia. Inflammopharmacology. 23:173-185.

• Fernando. W., D.W. Hoskin, and H.P.V. Rupasinghe. 2015. Regulation of hypoxia-inducible factor-1α and vascular endothelial growth factor signaling by plant flavonoids. Mini-reviews in Medicinal Chemistry. 15:479-489.

• Block, K., C. Gyllenhaal, L. Lowe, A. Amedei, A.R.M. Ruhul Amin, A. Amin, K. Aquilano, J. Arbiser, A.  Arreola, A. Arzumanyan, S.S. Ashraf, A.S. Azmi, F. Benencia, D. Bhakta, A. Bilsland, A. Bishayee, S.W. Blain, P. Block, C.S. Boosani, T.E. Carey, A. Carnero, M. Carotenuto, S.C. Casey, M. Chakrabarty, R. Chaturvedi, G.Z. Chen, H. Chen, S. Chen, Y.C. Chen, B.K. Choi, M.R. Ciriolo, H.M. Coley, A.R. Collins, M. Connell, S. Crawford, C. Dabrosin, G. Damia, S. Dasgupta, V.S. Dass, R.J. DeBerardinis, W.K. Decker, P. Dhawan, A.M.E. Diehl, J.-T. Dong, Q. P. Dou, J.E. Drew, E. Elkord, B. El-Rayes, M.A. Feitelson, D.W. Felsher, L.R Ferguson, C. Fimognari, G.L. Firestone, C. Frezza, H. Fujii, M. Fuster, D. Generali, A.G. Georgakilas, F. Gieseler, M. Gilbertson, M.F. Green, B. Grue, G. Guha, D. Halicka, W.G. Helferich, P. Heneberg, P. Hentosh, M.D. Hirschey, L.J. Hofseth, R.F. Holcombe, K. Honoki, H.-Y. Hsu, G.S. Huang, L.D. Jensen, W.G. Jiang, L.W. Jones, P.A. Karpowicz, W.N. Keith, S.P. Kerkar, G.N. Khan, M. Khatami, Y.H. Ko, O. Kucuk, R.J. Kulathinal, N.B. Kumar, S. Kumara, B.S. Kwon, A. Le, M.A. Lea, H.-Y. Lee, T. Lichtor, L.-T. Lin, J.W. Locasale, B.L. Lokeshwar, V.D. Longo, C.A. Lyssiotis, K.L. MacKenzie, M. Malholtra, M. Marino, M.L. Martinez-Chantar, A. Matheu, C. Maxwell, E. McDonnell, A.K. Meeker, M. Mehrmohamadi, K. Mehta, G.A. Michelotti, R.M. Mohammad, S. I. Mohammed, D.J. Morre, V. Muralidhar, M.P. Murphy, G. P. Nagaraju, R. Nahta, E. Niccolai, S. Nowsheen, C. Panis, F. Pantano, V.R. Parslow, G. Pawelec, P.L. Pedersen, B. Poore, D. Poudyal, S. Prakash, M. Prince, L. Raffaghello, J.C. Rathmell, W. K. Rathmell, S.K. Ray, J. Reichrath, S. Rezazadeh, D. Ribatti, L. Ricciardiello, F. Rodier, H.P.V. Rupasinghe, G.L. Russo, E.P. Ryan, A.K. Samadi, I. Sanchez-Garcia, A.J. Sanders, D. Santini, M. Sarkar, T. Sasada, N.K. Saxena, R.E. Shackelford, D. Sharma, D.M. Shin, D. Sidransky, M. D. Siegelin, E. Signori, N. Singh, S. Sivanand, D. Sliva, C. Smythe, C. Spagnuolo, D.M. Stafforini, J. Stagg, P.R. Subbarayan, T. Sundin, W.H. Talib, S. Thompson, P.T. Tran, H. Ungefroren, M.G.V. Heiden, V. Venkateswaran, P.J. Vlachostergios, Z. Wang, K.E. Wellen, R.L. Whelan, E.S. Yang, H. Yang, X. Yang, P. Yaswen, C. Yedjou, X. Yin, J. Zhu, M. Zollo. 2015. Designing a broad-spectrum integrative approach for cancer prevention and treatment – A review. Seminars in Cancer Biology. 35:S276-S304.

• Samadi, A.K., A. Bilsland, A.G. Georgakilas, A.S. Azmi, A. Amedei, A. Amin, A. Bishayee, B.L. Lokeshwar, B. Grue, C. Panis, C.S. Boosani, D. Poudyal, D.M. Stafforini, D. Bhakta, E. Niccolai, G. Guha, H.P.V. Rupasinghe, H. Fujii, K. Honoki, K. Mehta, K. Aquilano, L. Lowe, L.J. Hofseth, L. Ricciardiello, M.R. Ciriolo, N. Singh, R.L. Whelan, R. Chaturvedi, S.S. Ashraf, and H.M.C.S. Kumara. 2015. A multi-targeted approach to suppress tumor-promoting inflammation – A review. Seminars in Cancer Biology. 35:S151-S184.

• Bhullar, K.S. and H.P.V. Rupasinghe. 2015. Partridgeberry polyphenols protect primary cortical from oxygen-glucose deprivation-reperfusion induced injury via suppression of inflammatory adipokines and regulation of HIF-1α and PPARγ. Nutritional Neuroscience. (Available online: doi.org/10.1179/1476830515Y.0000000026).

• Balasuriya, N., H.P.V. Rupasinghe, M. Sweeney, S. McCarron, and K. Gottschall-Pass. 2015. Antihypertensive effects of apple peel extract on spontaneously hypertensive rats. Pharmacologia. 6:371-376.

Rupasinghe, H.P.V., M.A. Boehm, S. Sekhon-Loodu, I. Parmar, B. Bors, and A.R. Jamieson. 2015. Anti-inflammatory activity of haskap (Lonicera caerulea L.) cultivars is dependent on their polyphenol content. Biomolecules. 5:1079-1098.

• Sudan, S. and H.P.V. Rupasinghe. 2015. Antiproliferative activity of long chain acylated esters of quercetin-3-O-gluocoside in hepatocellular carcinoma HepG2 cells. Experimental Biology and Medicine. doi:10.1177/1535370215570828.

• Gunathilake, K.D.P.P. and H.P.V. Rupasinghe. 2015. Recent perspectives on the medicinal potential and chemistry of ginger. Botanics: Targets and Therapy. 5:55-63.

• Dessalegn, E., G. Bultosa, G.D. Haki, and H.P.V. Rupasinghe. 2015. Antioxidant and α-amylase inhibition activities in vitro of various solvent extracts of Thymus schimperi Ronniger. Journal of Medicinal Plant Research. 9:515-524.

• Parmar, I. and H.P.V. Rupasinghe. 2015. Antioxidant capacity and anti-diabetic activity of wild berry stem infusions. European Journal of Medicinal Plants. 8:11-28.

•  Sekhon-Loodu, S., A. Catalli, M. Kulka, Y. Wang, F. Shahidi and H.P.V. Rupasinghe. 2014. Combination of apple flavonols and omega-3 fatty acid-rich fish oil improves the efficacy of lowering blood C-reactive protein in rats with hypercholesterolemia and acute inflammation. Nutritional Research. 34:535-543.

•  Nair, S.V.G., Ziaullah, and H.P.V. Rupasinghe. 2014. Fatty acid esters of phloridzin induce apoptosis of human liver cancer cells through altered gene expression. PLoS ONE 9(9): e107149.

•  Sudan, S. and H.P.V. Rupasinghe. 2014. Flavonoid-enriched apple fraction induces cell cycle arrest, DNA topoisomerase II inhibition and apoptosis in human liver cancer HepG2 cells. Nutrition and Cancer. 66:1237-1246.

•  Paul, N.K., K.S. Bhullar, H.P.V. Rupasinghe, J. Balzarinic, and A. Jha. 2014. All trans 1-(3-arylacryloyl)-3,5-bis(pyridin-4-ylmethylene)piperidin-4-ones as curcumin-inspired antineoplastics. European Journal of Medicinal Chemistry. 87:461-470.

•  Bhullar, K.B., G. Lassalle-Claux, M. Touaibia, and H.P.V. Rupasinghe. 2014. Antihypertensive effect of caffeic acid and its analogs through dual renin-angiotensin-aldosterone system inhibition. European Journal of Pharmacology. 730:125-132.

•  Bhullar, K.B. and H.P.V. Rupasinghe. 2014. In vitro regulation of enzymes of the renin-angiotensin-aldosterone system by isoquercitrin, phloridzin and their long chain fatty acid derivatives. Functional Foods in Health and Disease. 4:208-221.

•  Warford, J., R. Quinton, D. Jones, M. Nichols, V. Sullivan, H.P.V. Rupasinghe, and G.S. Robertson. 2014. The flavonoid-enriched fraction AF4 suppresses neuroinflammation and promotes restorative gene expression in a mouse model of experimental autoimmune encephalomyelitis. Journal of Neuroinflammation. 268:71-83.

•  Sudan, S. and H.P.V. Rupasinghe. 2014. Quercetin-3-O-glucoside induces human DNA topoisomerase II inhibition, cell cycle arrest and apoptosis in hepatocellular carcinoma cells. Anti-cancer Research. 34:1691-1699.

•  Gunathilake, K.D.P.P. and H.P.V. Rupasinghe. 2014. Optimization of water based-extraction methods for the preparation of bioactive-rich ginger extract using response surface methodology. European Journal of Medicinal Plants. 4:893-906.

•  Nair, S.V.G., M. Hettihewa, and H.P.V. Rupasinghe. 2014. Apoptotic and inhibitory effects on cell proliferation of hepatocellular carcinoma HepG2 cells by methanol leaf extract of Costus speciosus. BioMed Research International. Volume 2014 Article ID 627098. 10 Pages. ttp://dx.doi.org/10.1155/2014/637098.

•  Sampson, D.J., Y.K. Chang, H.P.V. Rupasinghe, Q. Zaman. 2014. A dual-view computer-vision system for volume and image texture analysis in multiple apple slices drying. Journal of Food Engineering. 127:49-57.

•  Gunathilake, K.D.P.P. and H.P.V. Rupasinghe. 2014. Inhibition of human low density lipoprotein oxidation in vitro by ginger extracts. Journal of Medicinal Food. 17:424-431.

•  Ziaullah, K.S. Bhullar, S.N. Warnakulasuriya, H.P.V. Rupasinghe. 2013. Biocatalytic synthesis, structural elucidation, antioxidant capacity and tyrosinase inhibition activity of long chain fatty acid acylated derivatives of phloridzin and isoquercitrin. Biorganic and Medicinal Chemistry. 21:684-692.

•  Gunathilake, K.D.P.P., H.P.V. Rupasinghe, N.L. Pitts. 2013. Formulation and characterization of a bioactives-enriched fruit beverage designed for cardio-protection. Food Research International. 52:535-541.

•  Sekhon-Loodu, S., H.P.V. Rupasinghe, F. Shahidi. 2013. Antioxidant ability of fractionated apple peel phenolics to inhibit fish oil oxidation.  Food Chemistry 140:189-196.

•  Parmar, I. and H.P.V. Rupasinghe. 2013. Bio-conversion of apple pomace into ethanol and acetic acid: Enzymatic hydrolysis and fermentation. Bioresource Technology. 130:613-620.

•  Thilakarathna, S.H., H.P.V. Rupasinghe, and P.W. Needs. 2013. Apple peel bioactive rich extracts effectively inhibit in vitro human LDL oxidation. Food Chemistry 138:463-470.

•  Gunathilake, K.D.P.P., L.Yu, and H.P.V. Rupasinghe. 2013. Reverse osmosis as a potential technique to improve antioxidant properties of fruit juices used for functional beverages. Food Chemistry 148:335-341.

•  Gibson, L., H.P.V. Rupasinghe, C.F. Forney, and L. Eaton. 2013. Characterization of changes in polyphenols, antioxidant capacity and physico-chemical parameters during lowbush blueberry fruit ripening. Antioxidants 2:216-229.

•  Nandasiri, R. and H.P.V. Rupasinghe. 2013. Inhibition of low density lipoprotein oxidation and angiotensin converting enzyme in vitro by functional fruit vinegar beverages. Journal of Food Processing & Beverages. 1: 5-10.

•  Thilakarathna, S. and H.P.V. Rupasinghe. 2013. Flavonoid bioavailability and attempts for bioavailability enhancement. Nutrients 5:3367-3387.

•  Fikreyesus, S., T. Astatkie, and H.P.V. Rupasinghe. 2013. Antioxidant capacity, total phenolics and nutritional content in selected Ethiopian staple food ingredients International Journal of Food Sciences and Nutrition. 64:915-920.

•  Taylor, N., A.M. Hammermeister, H.P.V. Rupasinghe, K. Pruski. 2013. Characterization of Ribes nigrum in relation to fruit maturity and genotype. Acta Horticulturae 1001:199-205.

•  Gunathilake, K.D.P.P., H.P.V. Rupasinghe, and Y. Wang. 2013. Hypocholesterolemic and hypotensive effects of a fruit-based functional beverage in spontaneously hypertensive rats fed with cholesterol-rich diet.  J. Functional Foods. 5: 1392-1401.

•  Yu, L. and H.P.V. Rupasinghe. 2013. Improvement of cloud stability, yield and beta-carotene content of carrot juice by process modification. Food Sci. Technol. Int. 19:399-406.

•  Ziaullah, and H.P.V. Rupasinghe. 2013. An efficient microwave-assisted enzyme-catalyzed regioselective synthesis of long chain acylated derivatives of flavonoid glycosides.  Tetrahedron Letters 54:1933-1937.

•  Bhullar, K.S., A. Jha, D. Youssef, and H.P.V. Rupasinghe. 2013. Curcumin and its carbocyclic analogs: structure-activity in relation to antioxidant and selected biological properties. Molecules 18:5389-5404.

•  Gao, G. and H.P.V. Rupasinghe. 2013. Characterization of malolactic conversion by Oenococcus oeni to reduce the acidity of apple juice. International Journal of Food Science and Technology 48:1018-1027.

•  Chen, Y., L.J. Yu, and H.P.V. Rupasinghe. 2013. Effect of thermal and non-thermal pasteurization on the microbial inactivation and phenolic degradation in fruit juice: a Mini-review. Journal of the Science of Food and Agriculture. 93:981-986.

•  Keddy, P., K. Dunlop, J. Warford, M.L. Samson, Q.R.D. Jones, H.P.V. Rupasinghe, G.S. Robertson. 2012. Neuroprotective and anti-inflammatory effects of the flavonoid-enriched fraction AF4 in a mouse model of hypoxic-ischemia brain injury. PLoS ONE 7:1-18.

•  Jones, Q.R.D, J. Warford, H.P.V. Rupasinghe, G.S. Robertson. 2012. Target-based selection of flavonoids for neurodegenerative disorders. Trends in Pharmacological Sciences. 33:602-610.

•  Thilakarathna, S.H., Y. Wang, H.P.V. Rupasinghe, and K. Ghanam. 2012. Apple peel flavonoid- and triterpene-enriched extracts differentially affect cholesterol homeostasis in hamsters. Journal of Functional Foods. 4: 963-971.

•  Balasuriya, N. and H.P.V. Rupasinghe. 2012. Antihypertensive properties of flavonoid-rich apple peel extract. Food Chemistry. 135:2320-2325.

•  Thilakarathna, S.H. and H.P.V. Rupasinghe. 2012. Anti-atherosclerotic effects of fruit bioactive compounds: A review of current scientific evidence. Canadian Journal of Plant Science 92:407-419.

•  Rupasinghe, H.P.V., L. Yu, K. Bhullar, and B. Bors. 2012. Haskap (Lonicera caerulea): A new berry crop with high antioxidant capacity. Canadian Journal of Plant Science. 92:1311-1317.

•  Parmar, I. and H.P.V. Rupasinghe. 2012. Optimization of dilute acid-based pretreatment and application of laccase on apple pomace. Bioresource Technology. 124:433-439.

•  Ratnasooriya, C.C, and H.P.V. Rupasinghe, 2012. Extraction of phenolic compounds from grapes and their pomace using beta-cyclodextrin. Food Chemistry. 134:625-631.

•  Yu, L. and H.P.V. Rupasinghe. 2012. Effect of acidification on quality and shelf life of carrot juice. Canadian Journal of Plant Science. 92:1113-1120.

•  Ratnasooriya, C.C., H.P.V. Rupasinghe, and N.L. Pitts. 2012. Physiocochemical and sensory evaluation of non-alcoholic wine-like beverages prepared from selected grape cultivars. J. Nutr. Food Sci. 2: 1-6.

•  Glover, K.E., S. Budge, M. Rose, H.P.V. Rupasinghe, L. MacLaren,  J. Green- Johnson, and A. Fredeen. 2012. Effect of feeding fresh forage and marine algae on the fatty acid composition and oxidation of milk and butter. J. Dairy Science 95: 2797-809.

•  Erkan, N., Z. Tao, H.P.V. Rupasinghe, B.Uysal, and B.S. Oksal. 2012. Antibacterial Activities of Essential Oils Extracted from Leaves of Murraya koenigii L. by Solvent-Free Microwave Extraction and Hydro-Distillation. Natural Product Communications 7:121-124.

•  Gao, J. and H.P.V. Rupasinghe. 2012. Chracterization of ‘Honeycrisp’ and ‘McIntosh’ apple juice quality in relation to delayed cooling treatments. The Open Food Science Journal. 6, 12-15.

•  Gao, G. and H.P.V. Rupasinghe. 2012. Nutritional, Physicochemical and microbial quality of ultrasound-treated apple-carrot juice blends. Food and Nutrition Sciences. 3, 212-218.

•  Balasuriya, B.W.N. and H.P.V. Rupasinghe. 2011. Plant flavonoids as angiotensin converting enzyme inhibitors in regulation of hypertension. Functional Foods in Health and Diseases: 5:172-188.

•  Rupasinghe, H.P.V., P. Kathirvel, and G.M. Huber. 2011. Ultrasonication-assisted solvent extraction of quercetin glycosides from ‘Idared’ apple peels. Molecules 16: 9783-9791.

•  Proctor, J.T.A., J. A. Sullivan, H.P.V. Rupasinghe, and C-J. C. Jackson. 2011. Morphological and ginsenoside differences among north American ginseng leaves. J. Ginseng Res. 35:155-161.

•  Joshi, A.P.K., H.P.V. Rupasinghe and N.L. Pitts. 2011. Comparison of non-fried apple snacks with commercially available fried snacks. Food Sci. Technol. Internat.17: 249-255.

•  Joshi, A.P.K., H.P.V. Rupasinghe, and S. Khanizadeh. 2011. Impact of drying processes on bioactive phenolics, vitamin C and antioxidant capacity of red-fleshed apple slices. J. Food Proc. Preser. 35:453-457.

•  Joshi, A.P.K. and H.P.V. Rupasinghe. 2010. Optimization of bioactive fortification in apple snacks through vacuum impregnation using response surface methodology. Food Nutri. Sci. 2:45-52.

•  Joshi, A.P.K., H.P.V. Rupasinghe, and N.L. Pitts. 2010. Sensory and nutritional quality of the apple snacks prepared by vaccum impregnation process. J. Food Quality 33:758-767.

•  Rupasinghe, H.P.V., Ronalds, C.M., B. Rathgeber, and R. Robinson. 2010. Absorption and tissue distribution of dietary quercetin in broiler chickens. J. Sci. Food Agric. 90:1172-1178.

•  Rupasinghe, H.P.V., N. Erkan, and A. Yasmin. 2010. Antioxidant protection of eicosapentaenoic acid and fish oil oxidation by polyphenolic-enriched apple skin extract. J. Agric. Food Chem. 58:1233-1239.

•  Ratnasooriya, C., H.P.V. Rupasinghe, and A. Jamieson. 2010. Juice quality and polyphenol concentration of fresh fruits and pomace of selected Nova Scotia-grown grape cultivars. Can J. Plant Sc. 90:193-205.

•  Rupasinghe, H.P.V. and A. Yasmin. 2010. Inhibition of oxidation of aqueous emulsions of omega-3 fatty acids and fish oil by phloretin and phloridzin. Molecules 15:251-257.

•  Rupasinghe, H.P.V., Huber, G.M., C.G. Embree, and P.L. Forsline. 2010. Red-fleshed apple as a source for functional beverages. Can. J. Plant Sc. 90:95-100.

•  Huber, G.M. and H.P.V. Rupasinghe. 2009. Phenolic profiles and antioxidant properties of apple skin extracts. J. Food Sci. 74:693-700.

•  Rupasinghe, H.P.V., L. Wang, N.L. Pitts, and T. Astatkie. 2009. Baking and sensory characteristics of muffins incorporated with apple skin powder. J. Food Quality 32:685-694.

•  Huber, G.M., H.P.V. Rupasinghe, and F. Shahidi. 2009. Inhibition of oxidation of omega-3 polyunsaturated fatty acids and fish oil by quercetin glycosides. Food Chem. 117:290-295.

•  Hossain, M.A., S.M. Salehuddin, M.J. Kabir, S.M.M. Rahman, and H.P.V. Rupasinghe. 2009. Sinensetin, rutin, 3’-hydroxy-5, 6, 7, 4’-tetramethoxyflavone and rosmarinic acid contents and antioxidative effect of the skin of apple fruit. Food Chem. 113:185-190.

•  Khanizadeh, S., L. Ding, R. Tsao, D. Rekika, R. Yang, M.T. Charles, H.P.V. Rupasinghe. 2009. Phytochemical profiles of selected processing apple genotypes. Acta Hort. 814: 545-550.

•  Khanizadeh, S., R. Tsao, D. Rekika, R. Yang, M.T. Charles, H.P.V. Rupasinghe. 2009. Advances in fruit breeding in eastern Canada – Role of phytochemicals in designing specialty fruits. Acta Hort. 814: 205-208.

•  Hargreaves, J.C., M.S. Adl, P.R. Warman, and H.P.V. Rupasinghe. 2008. The effects of organic and conventional nutrient amendments on strawberry cultivation –Fruit yield and quality. J. Sci. Food Agric. 88:2669-2675.

•  Hargreaves, J.C., M.S. Adl, P.R. Warman, and H.P.V. Rupasinghe. 2008. The effects of organic amendments on mineral element uptake and fruit quality of raspberries. Plant & Soil. 308: 213-226.
 
•  Rupasinghe, H.P.V.  and C. Kean. 2008. Polyphenol concentrations in apple processing by-products determined using electrospray ionization mass spectrometry. Can J. Plant Sc. 88:759-762.

•  Muthuswamy, S., H.P.V. Rupasinghe, and G.W. Stratton. 2008. Antimicrobial effect of cinnamon bark extract on Escherichia coli O157:H7, Listeria innocua and fresh-cut apple slices. J. Food Safety 28:534-549.

•  Soundararajan, R., A.D. Wishart, H.P.V. Rupasinghe, M. Arcellana-Panlilio, C. M. Nelson, M. Mayne, and G.S. Robertson. 2008. Quercetin-3-glucoside protects neuroblastoma (SH-SY5Y) cells in vitro against oxidative damage by inducing SREBP-2 mediated cholesterol biosynthesis. J. Biol. Chem. 283: 2231-2245.

•  Khanizadeh, S., R. Tsao, D. Rekika, R. Yang, M.T. Charles, H.P.V. Rupasinghe. 2008. Polyphenol composition and total antioxidant capacity of selected apple genotypes for processing. J. Food Comp. Anal. 21:396-401.

•  Rupasinghe, H.P.V., L. Wang, G.M. Huber, and N.L. Pitts. 2008. Effect of baking on dietary fibre and phenolics of muffins incorporated with apple skin powder. Food Chem. 107:1217-1224.

 

Patent applications

•  Rupasinghe, H.P.V. et al. Antioxidant extract from fruit skin. A US provisional Patent application (61/014958); PCT Publication Number WO 2009/076776 A1 (Published on June 25, 2009).

•  Rupasinghe, H.P.V. et al. Non-fried apple food products processing for their preparation. A US provisional Patent application (61/106008) (submitted on October 16, 2008).

•  Rupasinghe, H.P.V. and G.S. Robertson. Phenolic compositions derived from apple skin and uses thereof in the prevention and treatment of oxidative stress. A US provisional Patent application (61/333,091) (submitted on May 10, 2010).

  Rupasinghe, H.P.V. et al.. Apple skin extracts for reduction of cholesterol levels. A US provisional Patent application (61/349,177) (submitted on May 27, 2010).