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Selected Recent Refereed Journal Publications

  • Merlin, J.P.P., G. Dellaire, K. Murphy, and H.P.V. Rupasinghe. 2021. Vitamin-containing antioxidant formulation reduces carcinogen-induced DNA damage through ATR/Chk1 signaling in bronchial epithelial cells in vitro. Biomedicines 9, 1665. biomedicines9111665.
  • De Silva, A.B.K.H. and H.P.V. Rupasinghe. 2021. Effect of growing location on anthocyanin content and total antioxidant capacity of haskap (Lonicera caerulea L.) berry: A preliminary investigation. Horticultural Science (Prague) 48:183-189.
  • Thilakarathna, W.P.D.W., C.H.J. Yu., H.P.V. Rupasinghe. 2021. Variations in nutritional and microbial composition of napa cabbage kimchi during refrigerated storage. Journal of Food Processing and Preservation. 00, e216065.
  • Dessalegn, E., and H.P.V. Rupasinghe. 2021. Phenolic compounds and in vitro antioxidant activity of Moringa stenopetala grown in South Ethiopia. International Journal of Food Properties. 24:1681-1692.
  • Yu, C.H.J. and H.P.V. Rupasinghe. 2021. Cannabidiol-based natural health products for companion animals: Recent advances in the management of anxiety, pain, and inflammation. Research in Veterinary Science. 140:38-46.
  • Latief, M., P.M. Sari, L.T. Fatwa, I.L. Tarigan, H.P.V. Rupasinghe. 2021. Antidiabetic activity of Sungkai (Peronema canescens Jack) leaves ethanol extract on the male mice induced by alloxan monohydrate. Pharmacology and Clinical Pharmacy Research. 6:64-74.
  • Merlin, J.P.P., H.P.V. Rupasinghe, G. Dellaire, and K. Murphy. 2021.  Role of dietary antioxidants in p53-mediated cancer chemoprevention and tumor suppression. Oxidative Medicine & Cellular Longevity. Article ID 9924328. 18 pages.
  • Watts, S., Z. Migicovsky, K.A. McClure, C.H.J. Yu, B. Amyotte, T. Baker, D. Bowlby, K. Burgher-MacLellan, L. Butler, R. Donald, L. Fan, S. Fillmore, J. Flewelling, K. Gardner, M. Hodges, T. Hughes, V. Jagadeesan, N. Lewis, E. MacDonell, L. MacVicar, M. McElroy, D. Money, M. O’Hara, Q. Ong, L. Campbell Palmer, J. Sawler, M. Vinqvist-Tymchuk, H.P.V. Rupasinghe, J. DeLong, C. Forney, J. Song, and S. Myles. 2021. Quantifying apple diversity: a phenomic characterization of Canada’s Apple Biodiversity Collection. Plants People Planet. 2021:00:1-14.
  • Murray, B., N. Arumuggam, T. Astatkie, and H.P.V. Rupasinghe. 2021. Phloridzin docosahexaenoate, a novel polyphenolic derivative, is cytotoxic to canine osteosarcoma D17 cells. Medical Research Archives. 9(6):1-8.
  • Natesh, N.H., M. Ijenyo, S.K. Asiedu, H.P.V. Rupasinghe, and L. Abbey. 2021. Plant growth and nutritional quality attributes of Malabar spinach (Basella alba L.) applied with variable rates of nitrogen fertilizer at different planting date under Canadian Maritime climatic conditions. International Journal of Agronomy. Article ID 5577696.
  • Zhang, S., J. Yang, S. Wang, H.P.V. Rupasinghe, Q. He. 2021. Experimental exploration of processes for deriving multiple products from spent coffee grounds.  Food and Bioproducts Processing. 128: 21-29.
  • Vazhappilly, C.G., M. Amararathna, A.C. Cyril, R. Linger, R. Matar, M. Merheb, W.S. Ramadan, R. Radhakrishnan, H.P.V. Rupasinghe. 2021. Current methodologies to refine bioavailability, delivery, and therapeutic efficacy of plant flavonoids in cancer treatment, The Journal of Nutritional Biochemistry. 2021: 108623.
  • Thilakarathna, W.P.D.W., H.P.V. Rupasinghe, and N.D. Ridgeway. 2021. Mechanisms by which probiotic bacteria attenuate the risk of hepatocellular carcinoma. International Journal of Molecular Sciences. 22(5):2606.
  • Wijesundara, N.M., S.F. Lee, Z. Cheng, R. Davidson, and H.P.V. Rupasinghe. 2021. Carvacrol exhibits rapid bactericidal activity against Streptococcus pyogenes through cell membrane damage. Nature Scientific Reports. 11:1487.
  • More Publications
  • Fernando, W., K. Goralski, D. Hoskin, and H.P.V. Rupasinghe. 2020. Metabolism and pharmacokinetics of a novel polyphenol fatty acid ester phloridzin docosahexaenoate in Balb/c female mice. Nature Scientific Report. 10:21391.
  • Rupasinghe, H.P.V. 2020. Flavonoids and their disease prevention and treatment potential: recent advances and future perspectives. Molecules. 2020, 25, 4746.
  • Suraweera, T.L., H.P.V. Rupasinghe, G. Dellaire, and Z. Xu. 2020. Regulation of Nrf2/ARE pathway by dietary flavonoids: A friend or foe for cancer management? Antioxidants. 9, 973; doi:10.3390/antiox9100973.
  • Muche, B.M., M. Jordan, C.F. Forney, R.A. Speers, and H.P.V. Rupasinghe. 2020. Effect of 1-methylcyclopropene (1-MCP) and storage atmosphere on the volatile aroma composition of cloudy and clear apple juices. Beverages. 2020, 6, 59; doi:10.3390/beverages6040059.
  • Rupasinghe, H.P.V., A. Davis, S.K. Kumar, B. Murray, and V.D. Zheljazkov. 2020. Industrial hemp (Cannabis sativa subsp. sativa) as an emerging source for value-added functional food ingredients and nutraceuticals. Molecules. 25, 4078; https://doi.org/10.3390/molecules25184078.
  • Dharmawansa, K.V.S., D.W. Hoskin, and H.P.V. Rupasinghe. 2020. Chemopreventive effect of dietary anthocyanins against gastrointestinal cancers: A review of recent advances and perspectives. International Journal of Molecular Sciences. 21, 6555; doi:10.3390/ijms21186555.
  • Amararathna, M., D.W. Hoskin, and H.P.V. Rupasinghe. 2020. Cyanidin-3-O-glucoside-rich haskap berry administration suppresses carcinogen-induced lung tumorigenesis in A/JCr mice. Molecules. 25, 3823; doi:10.3390/molecules25173823.
  • Siddiqui, S.S., S. Rahman, H.P.V. Rupasinghe, and C.G. Vazhappilly. 2020. Dietary flavonoids in p53-mediated immune dysfunctions linking to cancer prevention. Biomedicines. 8, 286; doi:10.3390/biomedicines8080286.
  • Hettihewa, S., Y. Hemar, and H.P.V. Rupasinghe. 2020. Comparative study of radical scavenging activity, antioxidant capacity and phenolic profiles of selected kiwifruit genotypes grown in New Zealand. International Journal of Recent Scientific Research. 11:38752-38757.
  • Hettihewa, S., Y. Hemar, and H.P.V. Rupasinghe. 2020. In vitro antioxidant activities and phenolic profiles of different solvent extracts obtained from Actinidia macrosperma, a wild kiwifruit. International Journal of Food and Nutrition. 5:92-96.
  • Gunathilake, K.D.P.P., K.K.D.S. Ranaweera, and H.P.V. Rupasinghe. 2020. Optimization of polyphenols and carotenoids extraction from leaves of Cassia auriculata for natural health products. Asian Plant Research Journal. 6:14-25.
  • Dessalegn, E., and H.P.V. Rupasinghe. 2020. Quantification of phenolic compounds by HPLC-DAD and in vitro antioxidant activity of root extract of Echinops kebericho Mesfin (Asteraceae). Chemical and Process Engineering Research. 62:6-13.
  • Dessalegn, E., G. Bultosa, G.D. Haki, and H.P.V. Rupasinghe. 2020. Effect of extraction solvents on total phenolic contents and in vitro antioxidant activity of the leaves of Lippia adoensis var. Koseret Sebsebe. 2020. Food Science and Quality Management. 94: 29-37.
  • Amararathna, M., D.W. Hoskin, H.P.V. Rupasinghe. 2020. Anthocyanin-rich haskap (Lonicera caerulea L.) berry extracts reduce nitrosamine-induced DNA damage in human normal lung epithelial cells in vitro. Food and Chemical Toxicology. 141:111404 (11 pages).
  • Chen, J., W.P.D.W. Thilakarathna, T. Astatkie, H.P.V. Rupasinghe. 2020. Optimization of catechin and proanthocyanidin recovery from grape seeds using microwave-assisted extraction. Biomolecules. 10, 243; doi:10.3390/biom10020243.
  • De Silva, A.B.K.H. and H.P.V. Rupasinghe. 2020. Polyphenols composition and anti-diabetic properties in vitro of haskap (Lonicera caerulea L.) berries in relation to cultivar and harvesting date. Journal of Food Composition and Analysis. 88:103402.
  • Mitsiogianni, M., T. Mantso, D.T. Trafalis, H.P.V. Rupasinghe, V. Zoumpourlis, R. Franco, S. Botaitis, A. Pappa, M.I. Panayiotidis. 2020. Allyl isothiocyanate regulates lysine acetylation and methylation marks in an experimental model of malignant melanoma. European Journal of Nutrition. 59:557–569.
  •  Mohd, A., Baig, M.H., and H.P.V. Rupasinghe. 2019. Impact of citral and phloretin, alone and in combination, on major virulence traits of Streptococcus pyogenes. Molecules. 24:4237; https://doi.org/10.3390/molecules24234237.
  • Fernando, W., K. Coyle, P. Marcato, H.P.V. Rupasinghe, and D. Hoskin. 2019. Phloridzin docosahexaenoate, a novel fatty acid ester of a plant polyphenol, inhibits mammary carcinoma cell metastasis. Cancer Letters. 465:68-81.
  • Loung, C-Y., W. Fernando, H.P.V. Rupasinghe, and D. Hoskin. 2019. Apple peel flavonoid fraction 4 (AF4) suppresses breast cancer cell growth by cytostatic and cytotoxic mechanisms. Molecules. 24:3355. Doi:10.3390/molecules24183335.
  • Wijesundara, N., H.P.V. Rupasinghe. 2019. Herbal tea for the management of pharyngitis: Inhibition of Streptococcus pyogenes growth and biofilm formation by herbal infusions. Biomedicines. 7(3), 63. doi.org/10.3390/biomedicines7030063.
  • George, V.C., S.A. Ansari, V.S. Chelakkot, A.L. Chelakkot, C. Chelakkot, V. Menon, W. Ramadan, K.R. Ethiraj, R. El-Awady, T. Mantso, M. Mitsiogianni, M.I. Panayiotidis, G. Dellaire, and H.P.V. Rupasinghe. 2019. DNA-dependent protein kinase: Epigenetic alterations and the role in genomic stability of cancer. Mutation Research/Reviews in Mutation Research. 780:92-105
  • Rupasinghe, H.P.V., I. Parmar, and S.V. Neir. 2019. Biotransformation of cranberry proanthocyanidins to probiotic metabolites by Lactobacillus rhamnosus enhances their anticancer activity in HepG2 cells in vitro. Oxidative Medicine and Cellular Longevity 2019, Article ID 4750795, 14 pages.
  • Amararathna, M., K. Goralski, H.P.V. Rupasinghe. 2019. Pulmonary nano-drug delivery systems targeted for lung cancer: Current knowledge and prospects. Journal of Lung Health and Disease. 3(2): 11-28.
  • Sekhon-Loodu, S. and H.P.V. Rupasinghe. 2019. Evaluation of antioxidant, antidiabetic and antiobesity potential of selected traditional medicinal plants. Frontiers in Nutrition. 6:53. doi: 10.3389/fnut.2019.00053.
  • Fernando, W., H.P.V. Rupasinghe, D.W. Hoskin.  2019. Dietary phytochemicals with anti-oxidant and pro-oxidant activities: A double-edged sword in relation to adjuvant chemotherapy and radiotherapy? Cancer Letters. 452:168-177.
  • Wijesundara, N., H.P.V. Rupasinghe. 2019. Bactericidal and anti-biofilm activity of ethanol extracts derived from selected medicinal plants against Streptococcus pyogenes. Molecules. 24, 1165; doi:10.3390/molecules24061165.
  • Mitsiogianni, M., T. Mantso, D.T. Trafalis, H.P.V. Rupasinghe, V. Zoumpourlis, R. Franco, S. Botaitis, A. Pappa, M.I. Panayiotidis. 2019. Allyl isothiocyanate regulates lysine acetylation and methylation marks in an experimental model of malignant melanoma. European Journal of Nutrition. doi.org/10.1007/s00394-019-01925-6.
  • Thilakarathna, W.P.D.W. and H.P.V. Rupasinghe. 2019. Microbial metabolites of proanthocyanidins reduce chemical carcinogen-induced DNA damage in human lung epithelial and fetal hepatic cells in vitro. Food and Chemical Toxicology. 125:479-493.
  • Gunathilake, K.D.P.P., K.K.D.S. Ranaweera, and H.P.V. Rupasinghe. 2019. Response surface optimization for recovery of polyphenols and carotenoids from leaves of Centella asiatica using an ethanol‐based solvent system. Food Science & Nutrition. 7:528-536.
  • Mantso, T., D.T. Trafalis, S. Botaitis, R. Franco, A. Pappa, H.P.V. Rupasinghe, and M.I. Panayiotidis. 2018. Novel docosahexaenoic acid ester of phloridzin inhibits proliferation and triggers apoptosis in an in vitro model of skin cancer. Antioxidants. 7, 188; doi:10.3390/antiox7120188. 1-12.
  • Gunathilake, K.D.P.P., K.K.D.S. Ranaweera, and H.P.V. Rupasinghe. 2018. In vitro anti-inflammatory properties of selected green leafy vegetables. Biomedicines. 6, 107/biomedicines6040107.1-10.
  • Muche, B.M., Alex Speers, and H.P. V. Rupasinghe. 2018.  Storage temperature impacts on anthocyanins degradation, color changes and haze development in the juice of ‘Merlot’ and ‘Ruby’ grapes (Vitis vinifera). Frontiers in Nutrition 5:Article100, 1-9.
  • George, V.C., …. H.P.V. Rupasinghe. 2018. DNA-dependent protein kinase: Epigenetic alterations and the role in genomic stability of cancer. Mutation Research – Reviews.
  • Hettihewa, S., Y. Hemar, and H.P.V. Rupasinghe. 2018. Flavonoid-rich extract of Actinidia macrosperma (a wild kiwifruit) inhibits the angiotensin-converting enzyme in vitro. Foods. 7, 146,  foods7090146.
  • Gunathilake, K.D.P.P., K.K.D.S. Ranaweera, and H.P.V. Rupasinghe. 2018. Effect of different cooking methods on polyphenols, carotenoids and antioxidant activities of selected edible leaves. Antioxidants. 7, 117, antiox7090117.
  • Gunathilake, K.D.P.P., K.K.D.S. Ranaweera, and H.P.V. Rupasinghe. 2018. Effects of in vitro gastro-intestinal digestion of selected leafy vegetables on anti-inflammatory properties. Annals. Food Science and Technology. 19:158-164.
  • Gunathilake, K.D.P.P., K.K.D.S. Ranaweera, and H.P.V. Rupasinghe. 2018. Analysis of rutin, β-carotene and lutein content and evaluation of antioxidant activities of six edible leaves on free radicals and reactive oxygen species. Journal of Food Biochemistry. e12579:1-9.
  • Adil, M., R. Khan, and H.P.V. Rupasinghe. 2018. Application of medicinal plants as a source for therapeutic agents against Streptococcus pyogenes infections. Current Drug Metabolism. 19:695-703.
  • ·       Knickle, A., W. Fernando, A.L. Greenshields, H.P.V. Rupasinghe, and D.W. Hoskin. 2018.  Myricetin-induced apoptosis of triple-negative breast cancer cells is mediated by the iron-dependent generation of reactive oxygen species from hydrogen peroxide. Food and Chemical Toxicology. 118:154-167.
  • ·       George, V.C. and H.P.V. Rupasinghe. 2018. DNA damaging and apoptotic potentials of Bisphenol A and Bisphenol S in human bronchial epithelial cells. 2018. Environmental Toxicology and Pharmacology. 60:52-57.
  • ·       Rupasinghe, H.P.V., N. Arumuggam, M. Amararathna, and A.B.K.H De Silva. 2018. The potential health benefits of haskap (Lonicera caerulea L.): Role of cyanidin-3-O-glucoside. Journal of Functional Foods. 44:24-39.
  • ·       Pace, E., Y. Jiang, A. Clemens, T. Crossman, and H.P.V. Rupasinghe. 2018. Impact of thermal degradation of cyanidin-3-O-glucoside of haskap berry on cytotoxicity of hepatocellular carcinoma HepG2 and breast cancer MDA-MB-231 cells. Antioxidants. 7(24):1-13. Antiox7020024.
  • ·       Thilakarathna, W.P.D.W., M. Langille, and H.P.V. Rupasinghe. 2018. Polyphenol-based prebiotics and synbiotics: potential for cancer chemoprevention. Current Opinion in Food Science. 20:51-57.
  • ·       Bhullar, K.S., N.O. Lagarón, E.M. McGowan, I. Parmar, A. Jha, B.P. Hubbard, and H.P.V. Rupasinghe. 2018. Kinase-targeted cancer therapies: progress, challenges and future directions. Molecular Cancer. 17:48 (1-20).
  • ·       Wijesundara, N. and H.P.V. Rupasinghe. 2018. Essential oils from Origanum vulgare and Salvia officinalis exhibit antibacterial and anti-biofilm activities against Streptococcus pyogenes. Microbial Pathogenesis. 117:118-127.
  • ·       Gunathilake, K.D.P.P., K.K.D.S. Ranaweera, and H.P.V. Rupasinghe. 2018. Influence of boiling, steaming, and frying of selected leafy vegetables on the in vitro anti-inflammation associated biological activities. Plants. 7:22 (1-10).
  • ·       Gunathilake, K.D.P.P., K.K.D.S. Ranaweera, and H.P.V. Rupasinghe. 2018. Changes of phenolics, carotenoids, and antioxidant capacity following simulated gastrointestinal digestion and dialysis of selected edible green leaves. Food Chemistry. 245:371-379.
  • ·       Gunathilake, K.D.P.P., K.K.D.S. Ranaweera, and H.P.V. Rupasinghe. 2017. Response surface optimization of phenolics and carotenoids extraction from leaves of Olax zeylanica. Annals. Food Science and Technology. 18:337-342.
  • ·       Gunathilake, K.D.P.P., K.K.D.S. Ranaweera, H.P.V. Rupasinghe, O.D.A.N. Perera, and H.P.S. Jayaweera. 2017. Response surface optimization of extraction of polyphenols and carotenoids from Sesbania grandiflora leaves with ethanol-water system. Asian Journal of Biotechnology and Bioresource Technology. 2:1-10.
  • ·       Arumuggam, N., N. Melong, C.L.K. Too, J.N. Berman, and H.P.V. Rupasinghe. 2017. Phloridzin docosahexaenoate, a novel flavonoid derivative, suppresses growth and induces apoptosis in T-cell acute lympholastic leukemia cells. American Journal of Cancer Research. 7:2452-2464.
  • George, V.C. and H.P.V. Rupasinghe. 2017. Apple flavonoids suppress carcinogens-induced DNA damage in normal human bronchial epithelial cells. Oxidative Medicine and Cellular Longevity. 2017: Article ID 1767198, 12 pages.
  • Xu, Z., R. Peng, X. Chen, R. Ghosh, and H.P.V. Rupasinghe. 2017. Isolation of flavonoids from apple peel using novel graphene oxide cotton fiber. Natural Product Research. 31(21):2559-2563.
  • Wijesundara, N. and H.P.V. Rupasinghe. 2017. Phytochemical-rich medicinal plant extracts suppress bacterial antigens-induced inflammation in human tonsil epithelial cells. PeerJ. 5:e3469.
  • Zhang, B., L. Abbey, and H.P.V. Rupasinghe. 2017. Growing medium amendments effect on growth, secondary metabolites and anti-streptococcal activity of two species of Plectranthus. Journal of Applied Research on Medicinal and Aromatic Plants. 5:53-59.
  • Gunathilake, K.D.P.P. and H.P.V. Rupasinghe. 2017. Optimization of phenolics and carotenoids extraction from leaves of Passiflora edulis using response surface methods. Asian Journal of Biotechnology and Bioresource Technology. 1:1-11.
  • George, V.C., G. Dellaire, H.P.V. Rupasinghe. 2017. Plant flavonoids in cancer chemoprevention: Role in genome stability. The Journal of Nutritional Biochemistry. 45:1-14.
  • Jiang, Y., L. Zhang, H.P.V. Rupasinghe. 2017. Antiproliferative effects of extracts from Salvia officinalis L. and Salivia miltiorrhiza Bunge on hepatocellular carcinoma cells. Biomedicine & Pharmacotheraphy. 85:57-67.
  • Fernando, W., M.R. Power-Coombs, D.W. Hoskin, H.P.V. Rupasinghe. 2016. Docosahexaenoic acid acylated-phloridzin, a novel polyphenol fatty acid ester derivative, is cytotoxic to breast cancer cells. Carcinogenesis 37:1004-1013.
  • Parmar, I., S.V. Nair, H.P.V. Rupasinghe. 2016. Polyphenol characterization, anti-oxidant, anti-proliferation and anti-tyrosinase activity of cranberry pomace. Functional Foods in Health and Disease. 6:754-768.
  • George, V.C, V.V. Vijesh, D.I.M. Amarararathna, C.A. Lakshmi, K. Anbarasu, D.R.N. Kumar, K.R. Ethiraj, R.A. Kumar, and H.P.V. Rupasinghe. 2016. Mechanism of action of flavonoids in prevention of inflammation-associated skin cancer. Current Medicinal Chemistry 23:1-20.
  • Amararathna, M., M.R. Johnston, H.P.V. Rupasinghe. 2016. Plant polyphenols as chemopreventive agents for lung cancer. International Journal of Molecular Sciences. 17:1352-1366.
  • Rupasinghe, H.P.V., S. Sekhon-Loodu, T. Mantso, M.I. Panayiotidis. 2016. Phytochemicals in regulating fatty acid β-oxidation: Potential underlying mechanisms and their involvement in obesity and weight loss. Pharmacology & Therapeutics. 165:153-163.
  • Warnakulasuriya, S.N., Ziaullah, and H.P.V. Rupasinghe. 2016. Novel long chain fatty acid derivatives of quercetin-3-O-glucoside reduce cytotoxicity induced by cigarette smoke toxicants in human fetal lung fibroblasts. European Journal of Pharmacology. 781:128-138.
  • Warnakulasuriya, S.N., Ziaullah, and H.P.V. Rupasinghe. 2016. Long chain fatty acid esters of quercetin-3-O-glucoside attenuate H2O2-induced acute cytotoxicity in human lung fibroblasts and primary hepatocytes. Molecules. 21:452-471.
  • Jiang, Y., L. Zhang, H.P.V. Rupasinghe. 2016. The anticancer properties of phytochemical extracts from Salvia plants. Botanics: Targets and Theraphy. 6:25-44.
  • Abachi, S., S. Lee and H.P.V. Rupasinghe. 2016. Molecular mechanisms of inhibition of streptococcus species by phytochemicals. Molecules. 21:215-246.
  • Ziaullah and H.P.V. Rupasinghe. 2016. Sonochemical enzyme-catalyzed regioselective acylation of flavonoid glycosides. Bioorganic Chemistry. 65:17-25.
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  • Duffield, K.M., M.R. Ness, K.S. Bhullar, H.P.V. Rupasinghe, J. Balzarini, A. Jha. 2015.  Curcumin-inspired cytotoxic 3,5-bis(arylmethylene)-1-(N-arylmaleamoyl)-4-piperidones: A novel group of topoisomerase II alpha inhibitors. Bioorganic & Medicinal Chemistry. 23:6404-6417.
  • ·       Bhullar, K.S. and H.P.V. Rupasinghe. 2015. Partridgeberry polyphenols protect primary cortical and hippocampal neurons against β-amyloid toxicity. Food Research International. 74: 237–249.
  • ·       Arumuggam, N., N.A. Bhowmick, H.P.V. Rupasinghe. 2015. Phytochemicals targeting JAK/STAT signaling and IDO expression in cancer. Phytotheraphy Research. 29:805-817.
  • ·       Sekhon-Loodu, S. Ziaullah, and H.P.V. Rupasinghe. 2015. Docosahexaenoic acid ester of phlorizin inhibit lipopolysaccharide-induced inflammation in THP-1 differentiated macrophages. International Immunopharmacology. 25:199-206.
  • ·       Caseya, S.C., A. Amedei, K. Aquilano, A.S. Azmi, F. Benencia, D. Bhakta, A.E. Bilsland, C.S. Boosani, S. Chen, M.R. Ciriolo, S. Crawford, H. Fujii, A.G. Georgakilas, G. Guha, D. Halicka, W.G. Helferich, P. Heneberg, K. Honoki, W.N. Keith, S.P. Kerkar, S.I. Mohammed, E. Niccolai, S. Nowsheen, H.P.V. Rupasinghe, A. Samadi, N. Singh, W.H. Talib, V. Venkateswaran, R.L. Whelan, and X. Yang. 2015. Cancer prevention and therapy through the modulation of the tumor microenvironment – A review. Seminars in Cancer Biology. 35:S199-S223.
  • Bhullar, K.B., A. Jha, and H.P.V. Rupasinghe. 2015. Novel carbocyclic curcumin analog CUR3d modulates genes involved in multiple apoptosis pathways in human hepatocellular carcinoma cells. Chemico-Biological Interactions. 242:107-122.
  • ·       Potter, E., M. Jha, K. Bhullar, H.P.V. Rupasinghe, J. Balzarini, and A. Jha. 2015. Investigation of fatty acid conjugates of 3,5-bisarylmethylene-4-piperidone derivatives as antitumor agents and human topoisomerase-IIα inhibitors. Journal of Bioorganic Chemistry. 23:411-421.
  • ·       Bhullar, K.B. and H.P.V. Rupasinghe. 2015. Antioxidant and cytoprotective properties of partridgeberry polyphenols. Food Chemistry. 168:595-605.
  • Sekhon-Loodu, S., Ziaullah, H.P.V. Rupasinghe, Y. Wang, M. Kulka, and F. Shahidi. 2015. Novel quercetin-3-O-glucoside eicosapentaenoic acid ester ameliorates inflammation and hyperlipidemia. Inflammopharmacology. 23:173-185.
  • ·       Fernando. W., D.W. Hoskin, and H.P.V. Rupasinghe. 2015. Regulation of hypoxia-inducible factor-1α and vascular endothelial growth factor signaling by plant flavonoids. Mini-reviews in Medicinal Chemistry. 15:479-489.
  • Block, K., C. Gyllenhaal, L. Lowe, A. Amedei, A.R.M. Ruhul Amin, A. Amin, K. Aquilano, J. Arbiser, A.  Arreola, A. Arzumanyan, S.S. Ashraf, A.S. Azmi, F. Benencia, D. Bhakta, A. Bilsland, A. Bishayee, S.W. Blain, P. Block, C.S. Boosani, T.E. Carey, A. Carnero, M. Carotenuto, S.C. Casey, M. Chakrabarty, R. Chaturvedi, G.Z. Chen, H. Chen, S. Chen, Y.C. Chen, B.K. Choi, M.R. Ciriolo, H.M. Coley, A.R. Collins, M. Connell, S. Crawford, C. Dabrosin, G. Damia, S. Dasgupta, V.S. Dass, R.J. DeBerardinis, W.K. Decker, P. Dhawan, A.M.E. Diehl, J.-T. Dong, Q. P. Dou, J.E. Drew, E. Elkord, B. El-Rayes, M.A. Feitelson, D.W. Felsher, L.R Ferguson, C. Fimognari, G.L. Firestone, C. Frezza, H. Fujii, M. Fuster, D. Generali, A.G. Georgakilas, F. Gieseler, M. Gilbertson, M.F. Green, B. Grue, G. Guha, D. Halicka, W.G. Helferich, P. Heneberg, P. Hentosh, M.D. Hirschey, L.J. Hofseth, R.F. Holcombe, K. Honoki, H.-Y. Hsu, G.S. Huang, L.D. Jensen, W.G. Jiang, L.W. Jones, P.A. Karpowicz, W.N. Keith, S.P. Kerkar, G.N. Khan, M. Khatami, Y.H. Ko, O. Kucuk, R.J. Kulathinal, N.B. Kumar, S. Kumara, B.S. Kwon, A. Le, M.A. Lea, H.-Y. Lee, T. Lichtor, L.-T. Lin, J.W. Locasale, B.L. Lokeshwar, V.D. Longo, C.A. Lyssiotis, K.L. MacKenzie, M. Malholtra, M. Marino, M.L. Martinez-Chantar, A. Matheu, C. Maxwell, E. McDonnell, A.K. Meeker, M. Mehrmohamadi, K. Mehta, G.A. Michelotti, R.M. Mohammad, S. I. Mohammed, D.J. Morre, V. Muralidhar, M.P. Murphy, G. P. Nagaraju, R. Nahta, E. Niccolai, S. Nowsheen, C. Panis, F. Pantano, V.R. Parslow, G. Pawelec, P.L. Pedersen, B. Poore, D. Poudyal, S. Prakash, M. Prince, L. Raffaghello, J.C. Rathmell, W. K. Rathmell, S.K. Ray, J. Reichrath, S. Rezazadeh, D. Ribatti, L. Ricciardiello, F. Rodier, H.P.V. Rupasinghe, G.L. Russo, E.P. Ryan, A.K. Samadi, I. Sanchez-Garcia, A.J. Sanders, D. Santini, M. Sarkar, T. Sasada, N.K. Saxena, R.E. Shackelford, D. Sharma, D.M. Shin, D. Sidransky, M. D. Siegelin, E. Signori, N. Singh, S. Sivanand, D. Sliva, C. Smythe, C. Spagnuolo, D.M. Stafforini, J. Stagg, P.R. Subbarayan, T. Sundin, W.H. Talib, S. Thompson, P.T. Tran, H. Ungefroren, M.G.V. Heiden, V. Venkateswaran, P.J. Vlachostergios, Z. Wang, K.E. Wellen, R.L. Whelan, E.S. Yang, H. Yang, X. Yang, P. Yaswen, C. Yedjou, X. Yin, J. Zhu, M. Zollo. 2015. Designing a broad-spectrum integrative approach for cancer prevention and treatment – A review. Seminars in Cancer Biology. 35:S276-S304.
  • ·       Samadi, A.K., A. Bilsland, A.G. Georgakilas, A.S. Azmi, A. Amedei, A. Amin, A. Bishayee, B.L. Lokeshwar, B. Grue, C. Panis, C.S. Boosani, D. Poudyal, D.M. Stafforini, D. Bhakta, E. Niccolai, G. Guha, H.P.V. Rupasinghe, H. Fujii, K. Honoki, K. Mehta, K. Aquilano, L. Lowe, L.J. Hofseth, L. Ricciardiello, M.R. Ciriolo, N. Singh, R.L. Whelan, R. Chaturvedi, S.S. Ashraf, and H.M.C.S. Kumara. 2015. A multi-targeted approach to suppress tumor-promoting inflammation – A review. Seminars in Cancer Biology. 35:S151-S184.
  • Bhullar, K.S. and H.P.V. Rupasinghe. 2015. Partridgeberry polyphenols protect primary cortical from oxygen-glucose deprivation-reperfusion induced injury via suppression of inflammatory adipokines and regulation of HIF-1α and PPARγ. Nutritional Neuroscience. (Available online: doi.org/10.1179/1476830515Y.0000000026).
  • Balasuriya, N., H.P.V. Rupasinghe, M. Sweeney, S. McCarron, and K. Gottschall-Pass. 2015. Antihypertensive effects of apple peel extract on spontaneously hypertensive rats. Pharmacologia. 6:371-376.
  • ·       Rupasinghe, H.P.V., M.A. Boehm, S. Sekhon-Loodu, I. Parmar, B. Bors, and A.R. Jamieson. 2015. Anti-inflammatory activity of haskap (Lonicera caerulea L.) cultivars is dependent on their polyphenol content. Biomolecules. 5:1079-1098.
  • ·       Sudan, S. and H.P.V. Rupasinghe. 2015. Antiproliferative activity of long chain acylated esters of quercetin-3-O-gluocoside in hepatocellular carcinoma HepG2 cells. Experimental Biology and Medicine. doi:10.1177/1535370215570828.
  • ·       Gunathilake, K.D.P.P. and H.P.V. Rupasinghe. 2015. Recent perspectives on the medicinal potential and chemistry of ginger. Botanics: Targets and Therapy. 5:55-63.
  • ·       Dessalegn, E., G. Bultosa, G.D. Haki, and H.P.V. Rupasinghe. 2015. Antioxidant and α-amylase inhibition activities in vitro of various solvent extracts of Thymus schimperi Ronniger. Journal of Medicinal Plant Research. 9:515-524.
  • Parmar, I. and H.P.V. Rupasinghe. 2015. Antioxidant capacity and anti-diabetic activity of wild berry stem infusions. European Journal of Medicinal Plants. 8:11-28.
  • Sekhon-Loodu, S., A. Catalli, M. Kulka, Y. Wang, F. Shahidi and H.P.V. Rupasinghe. 2014. Combination of apple flavonols and omega-3 fatty acid-rich fish oil improves the efficacy of lowering blood C-reactive protein in rats with hypercholesterolemia and acute inflammation. Nutritional Research. 34:535-543.
  • Nair, S.V.G., Ziaullah, and H.P.V. Rupasinghe. 2014. Fatty acid esters of phloridzin induce apoptosis of human liver cancer cells through altered gene expression. PLoS ONE 9(9): e107149.
  • Sudan, S. and H.P.V. Rupasinghe. 2014. Flavonoid-enriched apple fraction induces cell cycle arrest, DNA topoisomerase II inhibition and apoptosis in human liver cancer HepG2 cells. Nutrition and Cancer. 66:1237-1246.
  • Paul, N.K., K.S. Bhullar, H.P.V. Rupasinghe, J. Balzarinic, and A. Jha. 2014. All trans 1-(3-arylacryloyl)-3,5-bis(pyridin-4-ylmethylene)piperidin-4-ones as curcumin-inspired antineoplastics. European Journal of Medicinal Chemistry. 87:461-470.
  • Bhullar, K.B., G. Lassalle-Claux, M. Touaibia, and H.P.V. Rupasinghe. 2014. Antihypertensive effect of caffeic acid and its analogs through dual renin-angiotensin-aldosterone system inhibition. European Journal of Pharmacology. 730:125-132.
  • Bhullar, K.B. and H.P.V. Rupasinghe. 2014. In vitro regulation of enzymes of the renin-angiotensin-aldosterone system by isoquercitrin, phloridzin and their long chain fatty acid derivatives. Functional Foods in Health and Disease. 4:208-221.
  • Warford, J., R. Quinton, D. Jones, M. Nichols, V. Sullivan, H.P.V. Rupasinghe, and G.S. Robertson. 2014. The flavonoid-enriched fraction AF4 suppresses neuroinflammation and promotes restorative gene expression in a mouse model of experimental autoimmune encephalomyelitis. Journal of Neuroinflammation. 268:71-83.
  • Sudan, S. and H.P.V. Rupasinghe. 2014. Quercetin-3-O-glucoside induces human DNA topoisomerase II inhibition, cell cycle arrest and apoptosis in hepatocellular carcinoma cells. Anti-cancer Research. 34:1691-1699.
  • Gunathilake, K.D.P.P. and H.P.V. Rupasinghe. 2014. Optimization of water based-extraction methods for the preparation of bioactive-rich ginger extract using response surface methodology. European Journal of Medicinal Plants. 4:893-906.
  • Nair, S.V.G., M. Hettihewa, and H.P.V. Rupasinghe. 2014. Apoptotic and inhibitory effects on cell proliferation of hepatocellular carcinoma HepG2 cells by methanol leaf extract of Costus speciosus. BioMed Research International. Volume 2014 Article ID 627098. 10 Pages. ttp://dx.doi.org/10.1155/2014/637098.
  • Sampson, D.J., Y.K. Chang, H.P.V. Rupasinghe, Q. Zaman. 2014. A dual-view computer-vision system for volume and image texture analysis in multiple apple slices drying. Journal of Food Engineering. 127:49-57.
  • Gunathilake, K.D.P.P. and H.P.V. Rupasinghe. 2014. Inhibition of human low density lipoprotein oxidation in vitro by ginger extracts. Journal of Medicinal Food. 17:424-431.
  • Ziaullah, K.S. Bhullar, S.N. Warnakulasuriya, H.P.V. Rupasinghe. 2013. Biocatalytic synthesis, structural elucidation, antioxidant capacity and tyrosinase inhibition activity of long chain fatty acid acylated derivatives of phloridzin and isoquercitrin. Biorganic and Medicinal Chemistry. 21:684-692.
  • Gunathilake, K.D.P.P., H.P.V. Rupasinghe, N.L. Pitts. 2013. Formulation and characterization of a bioactives-enriched fruit beverage designed for cardio-protection. Food Research International. 52:535-541.
  • Sekhon-Loodu, S., H.P.V. Rupasinghe, F. Shahidi. 2013. Antioxidant ability of fractionated apple peel phenolics to inhibit fish oil oxidation.  Food Chemistry 140:189-196.
  • Parmar, I. and H.P.V. Rupasinghe. 2013. Bio-conversion of apple pomace into ethanol and acetic acid: Enzymatic hydrolysis and fermentation. Bioresource Technology. 130:613-620.
  • Thilakarathna, S.H., H.P.V. Rupasinghe, and P.W. Needs. 2013. Apple peel bioactive rich extracts effectively inhibit in vitro human LDL oxidation. Food Chemistry 138:463-470.
  • Gunathilake, K.D.P.P., L.Yu, and H.P.V. Rupasinghe. 2013. Reverse osmosis as a potential technique to improve antioxidant properties of fruit juices used for functional beverages. Food Chemistry 148:335-341.
  • Gibson, L., H.P.V. Rupasinghe, C.F. Forney, and L. Eaton. 2013. Characterization of changes in polyphenols, antioxidant capacity and physico-chemical parameters during lowbush blueberry fruit ripening. Antioxidants 2:216-229.
  • Nandasiri, R. and H.P.V. Rupasinghe. 2013. Inhibition of low density lipoprotein oxidation and angiotensin converting enzyme in vitro by functional fruit vinegar beverages. Journal of Food Processing & Beverages. 1: 5-10.
  • Thilakarathna, S. and H.P.V. Rupasinghe. 2013. Flavonoid bioavailability and attempts for bioavailability enhancement. Nutrients 5:3367-3387.
  • Fikreyesus, S., T. Astatkie, and H.P.V. Rupasinghe. 2013. Antioxidant capacity, total phenolics and nutritional content in selected Ethiopian staple food ingredients International Journal of Food Sciences and Nutrition. 64:915-920.
  • Taylor, N., A.M. Hammermeister, H.P.V. Rupasinghe, K. Pruski. 2013. Characterization of Ribes nigrum in relation to fruit maturity and genotype. Acta Horticulturae 1001:199-205.
  • Gunathilake, K.D.P.P., H.P.V. Rupasinghe, and Y. Wang. 2013. Hypocholesterolemic and hypotensive effects of a fruit-based functional beverage in spontaneously hypertensive rats fed with cholesterol-rich diet.  J. Functional Foods. 5: 1392-1401.
  • Yu, L. and H.P.V. Rupasinghe. 2013. Improvement of cloud stability, yield and beta-carotene content of carrot juice by process modification. Food Sci. Technol. Int. 19:399-406.
  • Ziaullah, and H.P.V. Rupasinghe. 2013. An efficient microwave-assisted enzyme-catalyzed regioselective synthesis of long chain acylated derivatives of flavonoid glycosides.  Tetrahedron Letters 54:1933-1937.
  • Bhullar, K.S., A. Jha, D. Youssef, and H.P.V. Rupasinghe. 2013. Curcumin and its carbocyclic analogs: structure-activity in relation to antioxidant and selected biological properties. Molecules 18:5389-5404.
  • Gao, G. and H.P.V. Rupasinghe. 2013. Characterization of malolactic conversion by Oenococcus oeni to reduce the acidity of apple juice. International Journal of Food Science and Technology 48:1018-1027.
  • Chen, Y., L.J. Yu, and H.P.V. Rupasinghe. 2013. Effect of thermal and non-thermal pasteurization on the microbial inactivation and phenolic degradation in fruit juice: a Mini-review. Journal of the Science of Food and Agriculture. 93:981-986.
  • Keddy, P., K. Dunlop, J. Warford, M.L. Samson, Q.R.D. Jones, H.P.V. Rupasinghe, G.S. Robertson. 2012. Neuroprotective and anti-inflammatory effects of the flavonoid-enriched fraction AF4 in a mouse model of hypoxic-ischemia brain injury. PLoS ONE 7:1-18.
  • Jones, Q.R.D, J. Warford, H.P.V. Rupasinghe, G.S. Robertson. 2012. Target-based selection of flavonoids for neurodegenerative disorders. Trends in Pharmacological Sciences. 33:602-610.
  • Thilakarathna, S.H., Y. Wang, H.P.V. Rupasinghe, and K. Ghanam. 2012. Apple peel flavonoid- and triterpene-enriched extracts differentially affect cholesterol homeostasis in hamsters. Journal of Functional Foods. 4: 963-971.
  • Balasuriya, N. and H.P.V. Rupasinghe. 2012. Antihypertensive properties of flavonoid-rich apple peel extract. Food Chemistry. 135:2320-2325.
  • Thilakarathna, S.H. and H.P.V. Rupasinghe. 2012. Anti-atherosclerotic effects of fruit bioactive compounds: A review of current scientific evidence. Canadian Journal of Plant Science 92:407-419.
  • Rupasinghe, H.P.V., L. Yu, K. Bhullar, and B. Bors. 2012. Haskap (Lonicera caerulea): A new berry crop with high antioxidant capacity. Canadian Journal of Plant Science. 92:1311-1317.
  • Parmar, I. and H.P.V. Rupasinghe. 2012. Optimization of dilute acid-based pretreatment and application of laccase on apple pomace. Bioresource Technology. 124:433-439.
  • Ratnasooriya, C.C, and H.P.V. Rupasinghe, 2012. Extraction of phenolic compounds from grapes and their pomace using beta-cyclodextrin. Food Chemistry. 134:625-631.
  • Yu, L. and H.P.V. Rupasinghe. 2012. Effect of acidification on quality and shelf life of carrot juice. Canadian Journal of Plant Science. 92:1113-1120.
  • Ratnasooriya, C.C., H.P.V. Rupasinghe, and N.L. Pitts. 2012. Physiocochemical and sensory evaluation of non-alcoholic wine-like beverages prepared from selected grape cultivars. J. Nutr. Food Sci. 2: 1-6.
  • Glover, K.E., S. Budge, M. Rose, H.P.V. Rupasinghe, L. MacLaren,  J. Green- Johnson, and A. Fredeen. 2012. Effect of feeding fresh forage and marine algae on the fatty acid composition and oxidation of milk and butter. J. Dairy Science 95: 2797-809.
  • Erkan, N., Z. Tao, H.P.V. Rupasinghe, B.Uysal, and B.S. Oksal. 2012. Antibacterial Activities of Essential Oils Extracted from Leaves of Murraya koenigii L. by Solvent-Free Microwave Extraction and Hydro-Distillation. Natural Product Communications 7:121-124.
  • Gao, J. and H.P.V. Rupasinghe. 2012. Chracterization of ‘Honeycrisp’ and ‘McIntosh’ apple juice quality in relation to delayed cooling treatments. The Open Food Science Journal. 6, 12-15.
  • Gao, G. and H.P.V. Rupasinghe. 2012. Nutritional, Physicochemical and microbial quality of ultrasound-treated apple-carrot juice blends. Food and Nutrition Sciences. 3, 212-218.
  • Balasuriya, B.W.N. and H.P.V. Rupasinghe. 2011. Plant flavonoids as angiotensin converting enzyme inhibitors in regulation of hypertension. Functional Foods in Health and Diseases: 5:172-188.
  • Rupasinghe, H.P.V., P. Kathirvel, and G.M. Huber. 2011. Ultrasonication-assisted solvent extraction of quercetin glycosides from ‘Idared’ apple peels. Molecules 16: 9783-9791.
  • Proctor, J.T.A., J. A. Sullivan, H.P.V. Rupasinghe, and C-J. C. Jackson. 2011. Morphological and ginsenoside differences among north American ginseng leaves. J. Ginseng Res. 35:155-161.
  • Joshi, A.P.K., H.P.V. Rupasinghe and N.L. Pitts. 2011. Comparison of non-fried apple snacks with commercially available fried snacks. Food Sci. Technol. Internat.17: 249-255.
  • Joshi, A.P.K., H.P.V. Rupasinghe, and S. Khanizadeh. 2011. Impact of drying processes on bioactive phenolics, vitamin C and antioxidant capacity of red-fleshed apple slices. J. Food Proc. Preser. 35:453-457.
  • Joshi, A.P.K. and H.P.V. Rupasinghe. 2010. Optimization of bioactive fortification in apple snacks through vacuum impregnation using response surface methodology. Food Nutri. Sci. 2:45-52.
  • Joshi, A.P.K., H.P.V. Rupasinghe, and N.L. Pitts. 2010. Sensory and nutritional quality of the apple snacks prepared by vaccum impregnation process. J. Food Quality 33:758-767.
  • Rupasinghe, H.P.V., Ronalds, C.M., B. Rathgeber, and R. Robinson. 2010. Absorption and tissue distribution of dietary quercetin in broiler chickens. J. Sci. Food Agric. 90:1172-1178.
  • Rupasinghe, H.P.V., N. Erkan, and A. Yasmin. 2010. Antioxidant protection of eicosapentaenoic acid and fish oil oxidation by polyphenolic-enriched apple skin extract. J. Agric. Food Chem. 58:1233-1239.
  • Ratnasooriya, C., H.P.V. Rupasinghe, and A. Jamieson. 2010. Juice quality and polyphenol concentration of fresh fruits and pomace of selected Nova Scotia-grown grape cultivars. Can J. Plant Sc. 90:193-205.
  • Rupasinghe, H.P.V. and A. Yasmin. 2010. Inhibition of oxidation of aqueous emulsions of omega-3 fatty acids and fish oil by phloretin and phloridzin. Molecules 15:251-257.
  • Rupasinghe, H.P.V., Huber, G.M., C.G. Embree, and P.L. Forsline. 2010. Red-fleshed apple as a source for functional beverages. Can. J. Plant Sc. 90:95-100.

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