Dr. Jian Wang received a master’s degree in physiology in 1989 from the Southeast University of Nanjing, China, where he served as a medical school teacher for several years. He received a master’s degree in audiology in 1998 and a PhD in hearing science in 2000 from the State University of New York at Buffalo. He joined the faculty at the School of Human Communication Disorders in 2001. He teaches basic courses in hearing science and instrumentation for audiology, as well as a seminar in selected topics in audiology.
Dr. Wang’s publications and presentations focus on a variety of topics in hearing science, including: cochlear gene therapy for the prevention of hearing loss due to aging, noise and ototoxic drugs, mechanisms of noise-induced hearing loss, and coding and plasticity in the auditory system induced by hearing loss.
Dr. Wang is currently the principal investigators of three national grants, two from CIHR supporting the research in cochlear gene therapy and relationship between hearing loss and cognitive impairment, and one from NSERC on the physiology of ribbon synapses in cochlea. He is also involved in collaborative research with two institutes in China and holds 3 research grants there as co-PI.
- BSc, Physiology, Nanjiing Medical College
- MA, Physiology, Southeast University of Nanjing
- MA, Audiology, State University of New York at Buffalo
- PhD, Hearing Sciences, State University of New York at Buffalo
- Ototoxicity and noise-induced hearing loss
- Cochlear gene therapy
- Auditory coding and plasticity
- Impact of hearing loss on cognitive function
- O'Leary TP, Shin S, Fertan E, Dingle RN, Almuklass A, Gunn RK, et al. Reduced acoustic startle response and peripheral hearing loss in the 5xFAD mouse model of Alzheimer's disease. Genes, brain, and behavior. 2017. DOI: 10.1111/gbb.12370
- Song Q, Shen P, Li X, Shi L, Liu L, Wang J, et al. Coding deficits in hidden hearing loss induced by noise: the nature and impacts. Scientific reports. 2016;6:25200.
- Shi L, Chang Y, Li X, Aiken SJ, Liu L, Wang J. Coding Deficits in Noise-Induced Hidden Hearing Loss May Stem from Incomplete Repair of Ribbon Synapses in the Cochlea. Front Neurosci. 2016;10:231. DOI: 10.3389/fnins.2016.00231
Shi L, Chang Y, Li X, Aiken S, Wang J. Cochlear Synaptopathy and Noise-induced Hidden Hearing Loss. Neural plasticity. 2016; 10.1155/2016/6143164.
- Shi L, Chang Y, Li X, Aiken S, Liu L, Wang J. Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss. Neural plasticity. 2016;2016: 6143164. Epub 2016 Sep 21. DOI: 10.1155/2016/6143164
- Salvi R, Sun W, Ding D, Chen GD, Lobarinas E, Wang J, et al. Inner Hair Cell Loss Disrupts Hearing and Cochlear Function Leading to Sensory Deprivation and Enhanced Central Auditory Gain. Front Neurosci. 2016;10:621.
- Liu L, Wang F, Lu H, Cao S, Du Z, Wang Y, et al. Effects of Noise Exposure on Systemic and Tissue-Level Markers of Glucose Homeostasis and Insulin Resistance in Male Mice. Environ Health Perspect. 2016;124(9):1390-8.
- Liu L, Shen P, He T, Chang Y, Shi L, Tao S, et al. Noise induced hearing loss impairs spatial learning/memory and hippocampal neurogenesis in mice. Scientific reports. 2016;6:20374.
- Guan J, Yi H, Zou J, Meng L, Tang X, Zhu H, et al. Distinct severity stages of obstructive sleep apnoea are correlated with unique dyslipidaemia: large-scale observational study. Thorax. 2016;71(4):347-55.
- Zhang J, Chen YC, Feng X, Yang M, Liu B, Qian C, et al. Impairments of thalamic resting-state functional connectivity in patients with chronic tinnitus. European journal of radiology. 2015.
- Zhang GY, Yang M, Liu B, Huang ZC, Chen H, Zhang PP, et al. Changes in the default mode networks of individuals with long-term unilateral sensorineural hearing loss. Neuroscience. 2015;285:333-42.
- Wang J, Song Q, Yu D, Yang G, Xia L, Su K, et al. Ontogenetic development of the auditory sensory organ in zebrafish (Danio rerio): changes in hearing sensitivity and related morphology. Scientific reports. 2015;5:15943.
- Shi, L., Guo, X., Shen, P., Liu, L., Tao, S., Li, X., Song, Q., Yu, Z., Yin, S., Wang, J. (2015). Noise-induced damage to ribbon synapses without permanent threshold shifts in neonatal mice. Neuroscience, 304: 368-377.
- Chen, Y. C., Li, X., Liu, L., Wang, J., Lu, C. Q., Yang, M., Jiao, Y., Zang, F. C., Radziwon, K., Chen, G. D., Sun W., Krishnan Muthaiah, V. P., Salvi, R., Teng, G.J. (2015). Tinnitus and hyperacusis involve hyperactivity and enhanced connectivity in auditory-limbic-arousal-cerebellar network. eLife 4:e06576.
- Chen, Y.C., Xia, W., Feng, Y., Li, X., Zhang, J., Feng, X., Wang, C.X., Cai, Y., Wang, J., Salvi, R., Teng, G.J. (2015). Altered interhemispheric functional coordination in chronic tinnitus patients. BioMed research international, 2015: 345647.
- Chen, Y.C., Zhang. J., Li, X.W., Xia, W., Feng, X., Qian, C., Yang, X.Y., Lu, C.Q., Wang, J., Salvi, R., Teng, G.J. (2015). Altered intra- and interregional synchronization in resting-state cerebral networks associated with chronic tinnitus. Neural plasticity 2015: 475382.
- Jie, H., Tao, S., Liu, L., Xia, L., Charko, A., Yu, Z., Bance, M., Yin, S., Robertson, G.S., Wang, J. (2015). Cochlear protection against cisplatin by viral transfection of X-linked inhibitor of apoptosis protein across round window membrane. Gene Ther. March 16, DOI: 10.1038/gt.2015.22
- Zhang, G.Y., Yang, M., Liu, B., Huang, Z.C., Chen, H., Zhang, P.P., Li, J., Chen, J.Y., Liu, L.J., Wang, J., Teng, G.J. (2015a). Changes in the default mode networks of individuals with long-term unilateral sensorineural hearing loss. Neuroscience, 285:333-342.
- Zhang, J., Chen, Y.C., Feng, X., Yang, M., Liu, B., Qian, C., Wang, J., Salvi, R., Teng, G.J. (2015). Impairments of thalamic resting-state functional connectivity in patients with chronic tinnitus. European journal of radiology. DOI：10.1016/j.ejrad. 2015.04.006
- Chen, Y.C., Zhang, J., Li, X.W., Xia, W., Feng, X., Gao, B., Ju, S.H., Wang, J., Salvi, R., Teng, G.J. (2014). Aberrant spontaneous brain activity in chronic tinnitus patients revealed by resting-state functional MRI. NeuroImage Clinical, 6: 222-228.
- Ruan, Q., Ao, H., He, J., Chen, Z., Yu, Z., Zhang, R., Wang, J., Yin, S. (2014), Topographic and quantitative evaluation of gentamicin-induced damage to peripheral innervation of mouse cochleae. Neurotoxicology, 40: 86-96.
- Ruan, Q., Zeng, S., Liu, A., Chen, Z., Yu, Z., Zhang, R., He, J., Bance, M., Robertson, G., Yin, S., Wang, J. (2014). Overexpression of X-Linked Inhibitor of Apoptotic Protein (XIAP) reduces age-related neuronal degeneration in the mouse cochlea. Gene Ther, 21: 967-974.
- Xia, L., Chen, Z., Su, K., Yin, S., Wang, J. (2014). Comparison of cochlear cell death caused by cisplatin, alone and in combination with furosemide. Toxicol Pathol, 42: 376-385.
- Ye, H.B., Wang, J., Zhang, W.T., Shi, H.B., Yin, S.K. (2013), Taurine attenuates bilirubin-induced neurotoxicity in the auditory system in neonatal guinea pigs. Int J Pediatr Otorhinolaryngol, 77: 647-654.
- Shi, L., Liu, L., He, T., Guo, X., Yu, Z., Yin, S., Wang, J. (2013). Ribbon synapse plasticity in the cochleae of guinea pigs after noise-induced silent damage. PLoS One 8:e81566.
- Liu, L., Wang, H., Shi, L., Almuklass, A., He, T., Aiken, S., Bance, M., Yin, S., Wang, J. (2012). Silent damage of noise on cochlear afferent innervation in guinea pigs and the impact on temporal processing. PLoS One 7:e49550.
- Wang, H., Murphy, R., Taaffe, D., Yin, S., Xia, L., Hauswirth, W.W., Bance, M., Robertson, G.S., Wang, J. (2012). Efficient cochlear gene transfection in guinea-pigs with adeno-associated viral vectors by partial digestion of round window membrane. Gene Ther, 19: 255-263.
- Ye, H.B., Shi, H.B., Wang, J., Ding, D.L., Yu, D.Z., Chen, Z.N., Li, C.Y., Zhang, W.T., Yin, S.K. (2012). Bilirubin induces auditory neuropathy in neonatal guinea pigs via auditory nerve fiber damage. J Neurosci Res, 90: 2201-2213.
- Xia, L., Yin, S., Wang, J. (2012). Inner ear gene transfection in neonatal mice using adeno-associated viral vector: a comparison of two approaches. PLoS One 7:e43218.
- Wang, H., Yin, S., Yu, Z., Huang, Y., Wang, J. (2011). Dynamic changes in hair cell stereocilia and cochlear transduction after noise exposure. Biochem Biophys Res Commun, 409: 616-621.
- Wang, J., Tymczyszyn, N., Yu, Z., Yin, S., Bance, M., Robertson, G.S. (2011). Overexpression of X-linked inhibitor of apoptosis protein protects against noise-induced hearing loss in mice. Gene Ther, 18: 560-568.