Vasantha Rupasinghe

Associate Professor


CONTACT INFORMATION

Department of Environmental Sciences
Email: vrupasinghe@dal.ca
Phone: (902) 893.6623
Mailing Address: 
Faculty of Agriculture, Dalhousie University
Rm 219-C Cox Institute Building
50 Pictou Rd. PO Box 550
Truro, NS, B2N 5E3
 

Teaching

Undergraduate

  • CHEM 3001 Biochemistry (Formerly Biochemical Pathways)
  • FOOD 3001 Functional Foods and Nutraceuticals
  • FOOD 4000 Directed Studies in Food & Bioproduct Science

Graduate

  • AGRI 5730 Directed Studies in Food & Bioproduct Science
  • AGRI 5710 Graduate module: Plant Secondary Metabolites
  • AGRI 5710 Graduate module: Biochemistry of Fruit Ripening
  • AGRI 5710 Mass Spectrometry: Fundamentals and Applications (with Dr. J. Hoyle)

Research Interests

Natural products chemistry; plant secondary metabolites: phenolics and isoprenoids; structure-activity relationship of flavonoids; bio-active phytochemicals of fruits, their health benefits and mode of action.

Development and evaluation of value-added health food and feed ingredients, natural food additives, functional foods, natural health products and other horticultural bio-products.

Postharvest biology and technology of fruits; biochemistry of fruits; fresh-cut and minimally processed technologies; shelf life and quality.

 

Memberships

  • Adjunct Professor, Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia.
  • Adjunct Professor, Department Process Engineering & Applied Sciences, Dalhousie University, Halifax, Nova Scotia.
  • Adjunct Professor, Department of Food Science and Nutrition, Addis Ababa University, Addis Ababa, Ethiopia.
  • Chair, Canadian Institute of Food Science and Technology (CIFST) - Atlantic Section.
  • Food Research Review Panel, Agriculture and Agri-Food Canada (AAFC) - 2009-2010.

Memberships continued

Publications

  • Ziaullah, K.S. Bhullar, S.N. Warnakulasuriya, H.P.V. Rupasinghe. 2013. Biocatalytic synthesis, structural elucidation, antioxidant capacity and tyrosinase inhibition activity of long chain fatty acid acylated derivatives of phloridzin and isoquercitrin. Biorganic and Medicinal Chemistry. 21:684-692.
  • Gunathilake, K.D.P.P., H.P.V. Rupasinghe, N.L. Pitts. 2013. Formulation and characterization of a bioactives-enriched fruit beverage designed for cardio-protection. Food Research International. 52:535-541.
  • Sekhon-Loodu, S., H.P.V. Rupasinghe, F. Shahidi. 2013. Antioxidant ability of fractionated apple peel phenolics to inhibit fish oil oxidation.  Food Chemistry 140:189-196.
  • Parmar, I. and H.P.V. Rupasinghe. 2013. Bio-conversion of apple pomace into ethanol and acetic acid: Enzymatic hydrolysis and fermentation. Bioresource Technology. 130:613-620.
  • Thilakarathna, S.H., H.P.V. Rupasinghe, and P.W. Needs. 2013. Apple peel bioactive rich extracts effectively inhibit in vitro human LDL oxidation. Food Chemistry 138:463-470.

More publications

 

Conference Proceedings

  •  Fernando, W., H.P.V. Rupasinghe, and D.W. Hoskin. 2013. Anti-proliferative activity of  phloridzin and its derivative in breast adenocarcinoma cells. Accepted for the 2013 Canadian Cancer Research Conference, Toronto, ON (Nov 3-6, 2013).
  • Bhullar, K.S., H.P.V. Rupasinghe, and A. Jha. 2013. A carbocyclic analog of curcumin inhibits cancer cell proliferation by multiple signaling pathways. Accepted for the 2013 Canadian Cancer Research Conference, Toronto, ON (Nov 3-6, 2013).
  • Sudan, S. and H.P.V. Rupasinghe. 2013. Apple flavonoids induces cell cycle arrest, DNA topoisomerase II inhibition and apoptosis in human liver cancer cells. Accepted for the 2013 Canadian Cancer Research Conference, Toronto, ON (Nov 3-6, 2013).
  • Nair, S.V.G., M. Hettihewa, H.P.V. Rupasinghe. 2013. Methanolic leaf extract of Costus speciosus induces apoptosis in human hepatocellular carcinoma cells. Accepted for the 2013  Canadian Cancer Research Conference, Toronto, ON (Nov 3-6, 2013).
  • Rupasinghe, H.P.V., Bhullar, K.S., and Ziaullah. 2013. Biocatalytic synthesis, structural elucidation, and tyrosinase inhibition activity of long chain fatty acid acylated derivatives of phloridzin and isoquercitrin. The 246th American Chemical Society (ACS) National Meeting. Indianapolis, IN, USA (September 8-12, 2013).
  • Rupasinghe, H.P.V., Bhullar, K.S., A. Jha. 2013. Antitumor activity of novel curcumin analogs in hepatocarcinoma (HepG2) cells. The 246th American Chemical Society (ACS) National Meeting. Indianapolis, IN, USA (September 8-12, 2013).
  • Sekhon-Loodu, S., H.P.V. Rupasinghe, Y. Wang and F. Shahidi. 2013. Apple flavonols, omega-3 fatty acid rich fish oil and their combination modulate lipid metabolism in hyperlipidemic rats. The 6th Maritime Natural Products Chemistry Conference. St. Francis Xavier University, Antagonish, NS. (August 12-14, 2013).
  • Sudan, S. and H.P.V. Rupasinghe. 2013. Quercetin-3-O-glucoside induces human DNA topoisomerase II inhibition, cell cycle arrest and apoptosis in HepG2 cells. The 6th Maritime Natural Products Chemistry Conference. St. Francis Xavier University, Antagonish, NS. (August 12-14, 2013).
  • Warnakulasuriya, S. and H.P.V. Rupasinghe. 2013. Cytoprotective effect of long chain fatty acid derivatives of Q3G against H2O2-induced oxidative stress in human lung fibroblasts and primary hepatocytes. The 6th Maritime Natural Products Chemistry Conference. St. Francis Xavier University, Antagonish, NS. (August 12-14, 2013).
  • Bhullar, K.S., G. Lassalle-Claux, M. Touaibia, and H.P.V. Rupasinghe. 2013. Antihypertensive activity of caffeic acid derivatives via inhibition of angiotensin converting enzyme (ACE) and renin in vitro. The 6th Maritime Natural Products Chemistry Conference. St. Francis Xavier University, Antagonish, NS. (August 12-14, 2013).
  • Parmar, I., S. Sharma, and H.P.V. Rupasinghe. 2013. Optimization of β-cyclodextrin-based flavonol extraction from apple pomace using response surface methodology. The 6th Maritime Natural Products Chemistry Conference. St. Francis Xavier University, Antigonish, NS. (August 12-14, 2013).
  • Grue, B. and H.P.V. Rupasinghe. 2013. Effect of Partridgeberry Bioactives on Nickel-induced Lung Fibroblast Cytotoxicity. The 6th Maritime Natural Products Chemistry Conference. St. Francis Xavier University, Antagonish, NS. (August 12-14, 2013).
  • Bhullar, K.S., Ziaullah, H.P.V. Rupasinghe. 2013. Effect of structural modification of flavonoids on their antihypertensive activity. The 6th Maritime Natural Products Chemistry Conference. St. Francis Xavier University, Antagonish, NS. (August 12-14, 2013).
  • Curry, W. and H.P.V. Rupasinghe. 2013. Antihypertensive properties of phytochemical extracts of haskap. Science Atlantic’s ChemCon Conference 2013. Memorial University of New Foundland. St. John’s, NL. (May 21-23, 2013).
  • Bhullar, K.S., A. Jha, D. Youssef, and H.P.V. Rupasinghe. 2012, Anticancer and Antioxidant Properties of Curcumin and its Analogues. The BHCRI 4th Annual Cancer Research Conference in Atlantic Canada, Halifax, NS. (November 4-6, 2012).

Selected Invited Presentations

  • Biological properties of fruit flavonoids and their acylated derivative long chain fatty acids. Acadia Unibersity. Wolfville, NS (October 24, 2013).
  • Biocatalytic synthesis, structural elucidation, and Biological activity of long chain fatty acid acylated derivatives of phloridzin and isoquercitrin. The 246th American Chemical Society (ACS) National Meeting. Indianapolis, IN, USA (September 8-12, 2013).